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uPAR/CD87 [10G7]
Description Urokinase plasminogen activator receptor (uPAR), also designated CD87, is a glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in Fibrin and Fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. This pathway is observed during re-epithelialization of lesions, wound healing and tissue remodeling. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial origin tumor cells and are required for tumor invasion and metastasis. Ras, MEK, ERK and MLCK function as downstream effectors in the uPAR-dependent signaling cascade, which is initiated by uPA binding, and promotes cellular migration in an integrin selective manner. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Indirect Flow cytometry (FC), IP, Western Blot (WB) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
uPAR/CD87 [10G7]
Description Urokinase plasminogen activator receptor (uPAR), also designated CD87, is a glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in Fibrin and Fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. This pathway is observed during re-epithelialization of lesions, wound healing and tissue remodeling. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial origin tumor cells and are required for tumor invasion and metastasis. Ras, MEK, ERK and MLCK function as downstream effectors in the uPAR-dependent signaling cascade, which is initiated by uPA binding, and promotes cellular migration in an integrin selective manner. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Indirect Flow cytometry (FC), IP, Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD68 [KP1]
Description CD68 is expressed on macrophages and monocytes. KP -1 is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. KP-1 reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Tumors of lymphoid origin are usually not stained. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rabbit, Monkey, Cat
7 ml more info 14 days
€187,20 Add to cart -
CD7 [MD146]
Description CD7 is a single-pass type 1 transmembrane protein that is a member of the immunoglobulin superfamily. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 is expressed on thymocytes, T- and natural killer cells, and progenitors of lymphoid and myeloid cells. It is also expressed on Tcell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. CD7 antibody is the most sensitive and specific T-cell deletion marker. Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of mycosis fungoides (MF) and cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
CD7 [MD146]
Description CD7 is a single-pass type 1 transmembrane protein that is a member of the immunoglobulin superfamily. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 is expressed on thymocytes, T- and natural killer cells, and progenitors of lymphoid and myeloid cells. It is also expressed on Tcell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. CD7 antibody is the most sensitive and specific T-cell deletion marker. Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of mycosis fungoides (MF) and cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD71 (Transferrin Receptor) [TFRC/1817]
Description CD71, the transferrin receptor, is a type II trans-membrane homodimer glycoprotein (180 kDa) involved in the cellular uptake of iron via internalization of iron-loaded transferring. CD71 is highly expressed in immature erythroid cells, placental tissue and rapidly dividing cells. Loss of CD71 is observed in mature erythrocytes. Over expression of CD71 has also been described for various types of cancers including lung, colon, breast and pancreas. CD71 antibody is useful in identifying erythroid precursors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
CD71 (Transferrin Receptor) [TFRC/1817]
Description CD71, the transferrin receptor, is a type II trans-membrane homodimer glycoprotein (180 kDa) involved in the cellular uptake of iron via internalization of iron-loaded transferring. CD71 is highly expressed in immature erythroid cells, placental tissue and rapidly dividing cells. Loss of CD71 is observed in mature erythrocytes. Over expression of CD71 has also been described for various types of cancers including lung, colon, breast and pancreas. CD71 antibody is useful in identifying erythroid precursors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD74 [LN-2]
Description Cluster of Differentiation 74 (CD74) is a type II transmembrane protein. In normal tissues, CD74 is expressed in B cells, monocytes, macrophages, Langerhans cells, dendritic cells, subsets of activated T cells, and thymic epithelium. Under inflammatory conditions, CD74 expression may be observed in endothelial and certain epithelial cells. CD74 expression has been observed in ~90% of B-cell cancers evaluated, as well as the majority of cell lines derived from these cancers.CD74 is a marker for distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and it is also a useful marker for distinguishing leiomyosarcoma from leiomyoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Baboon, Mouse
1 ml more info 14 days
€361,40 Add to cart -
CD74 [LN-2]
Description Cluster of Differentiation 74 (CD74) is a type II transmembrane protein. In normal tissues, CD74 is expressed in B cells, monocytes, macrophages, Langerhans cells, dendritic cells, subsets of activated T cells, and thymic epithelium. Under inflammatory conditions, CD74 expression may be observed in endothelial and certain epithelial cells. CD74 expression has been observed in ~90% of B-cell cancers evaluated, as well as the majority of cell lines derived from these cancers.CD74 is a marker for distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and it is also a useful marker for distinguishing leiomyosarcoma from leiomyoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Baboon, Mouse
7 ml more info 14 days
€187,20 Add to cart -
CD79a [JCB117]
Description CD79 consist of two proteins, CD79a (mb-1) and CD79b (B29). CD79a recognizes the Ig-alpha protein, and CD79b recognizes the Ig-beta protein of the B-cell antigen component of the B-lymphocyte antigen receptor. The expression of CD79 precedes immunoglobulin (Ig) gene, heavy-chain gene rearrangement and CD20 expression. In precursor B cells, the CD79 protein chains are already expressed in the cytoplasm (CyCD79). Surface expression of CD79 begins at the pro-B cell stage and persists throughout the B-cell differentiation, and continues presents on plasma cells. CD79a is an excellent marker for identification of normal and neoplastic B lymphocytes. This CD79a antibody has been validated by the 9th International Conference on Human Leukocyte Differentiation Antigens (HLDA9). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart
