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Tyrosinase [T311 + OCA1/812]
Description Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Tyrosinase catalyzes the hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine (DOPA). Oxidation reactions of DOPA to L-Dopaquinone and 5,6-dihydroxyindole (DHI) to indole-quinone occur spontaneously at physiological pH. Tyrosinase is expressed in melanin-producing cells such as melanocytes, which are primarily localized in the skin, hair bulbs and eyes. Low levels of tyrosinase mRNA was also detected in the human substantia nigra, but immunohistochemically unreactive. Since melanomas arise from melanocytes, there is evidence that tyrosinase is expressed in malignant melanomas. Studies have shown that tyrosinase is a sensitive and reliable marker to assess melanocytic lesions in paraffin-embedded tissue (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Tyrosinase-Related Protein-1 (TYRP-1) [SPM611]
Description It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TYRP-1). It is involved in melanin synthesis. TYRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TYRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TYRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
CD68 [KP1]
Description CD68 is expressed on macrophages and monocytes. KP -1 is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. KP-1 reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Tumors of lymphoid origin are usually not stained. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rabbit, Monkey, Cat
7 ml more info 14 days
€187,20 Add to cart -
CD7 [MD146]
Description CD7 is a single-pass type 1 transmembrane protein that is a member of the immunoglobulin superfamily. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 is expressed on thymocytes, T- and natural killer cells, and progenitors of lymphoid and myeloid cells. It is also expressed on Tcell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. CD7 antibody is the most sensitive and specific T-cell deletion marker. Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of mycosis fungoides (MF) and cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
CD7 [MD146]
Description CD7 is a single-pass type 1 transmembrane protein that is a member of the immunoglobulin superfamily. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 is expressed on thymocytes, T- and natural killer cells, and progenitors of lymphoid and myeloid cells. It is also expressed on Tcell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. CD7 antibody is the most sensitive and specific T-cell deletion marker. Loss of CD7 expression by neoplastic lymphocytes is considered a distinguishing characteristic of mycosis fungoides (MF) and cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD71 (Transferrin Receptor) [TFRC/1817]
Description CD71, the transferrin receptor, is a type II trans-membrane homodimer glycoprotein (180 kDa) involved in the cellular uptake of iron via internalization of iron-loaded transferring. CD71 is highly expressed in immature erythroid cells, placental tissue and rapidly dividing cells. Loss of CD71 is observed in mature erythrocytes. Over expression of CD71 has also been described for various types of cancers including lung, colon, breast and pancreas. CD71 antibody is useful in identifying erythroid precursors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
CD71 (Transferrin Receptor) [TFRC/1817]
Description CD71, the transferrin receptor, is a type II trans-membrane homodimer glycoprotein (180 kDa) involved in the cellular uptake of iron via internalization of iron-loaded transferring. CD71 is highly expressed in immature erythroid cells, placental tissue and rapidly dividing cells. Loss of CD71 is observed in mature erythrocytes. Over expression of CD71 has also been described for various types of cancers including lung, colon, breast and pancreas. CD71 antibody is useful in identifying erythroid precursors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD73/NT5E [D7F9A]
Description Ecto-5’-nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored, membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleosides. NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine monophosphate, which drives the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors. Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promoter leads to upregulation of NT5E during hypoxia (3). The biological roles of NT5E include lymphocyte adhesion, fibrosis (6), and the regulation of nociception. NT5E/CD73 (D7F9A) Rabbit mAb recognizes endogenous levels of total NT5E/CD73 protein (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€494,00 Add to cart -
CD73/NT5E [D7F9A]
Description Ecto-5’-nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored, membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleosides. NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine monophosphate, which drives the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors. Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promoter leads to upregulation of NT5E during hypoxia (3). The biological roles of NT5E include lymphocyte adhesion, fibrosis (6), and the regulation of nociception. NT5E/CD73 (D7F9A) Rabbit mAb recognizes endogenous levels of total NT5E/CD73 protein (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€267,80 Add to cart -
CD74 [LN-2]
Description Cluster of Differentiation 74 (CD74) is a type II transmembrane protein. In normal tissues, CD74 is expressed in B cells, monocytes, macrophages, Langerhans cells, dendritic cells, subsets of activated T cells, and thymic epithelium. Under inflammatory conditions, CD74 expression may be observed in endothelial and certain epithelial cells. CD74 expression has been observed in ~90% of B-cell cancers evaluated, as well as the majority of cell lines derived from these cancers.CD74 is a marker for distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and it is also a useful marker for distinguishing leiomyosarcoma from leiomyoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Baboon, Mouse
1 ml more info 14 days
€361,40 Add to cart
