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TROP2/TACD1 [B-9]
Description TROP2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factorlike repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
TROP2/TACD1 [B-9]
Description TROP2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factorlike repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
VEGF/VEGFA [VG1]
Description VEGF is a dimeric glycoprotein with structural homology to PDGF. Several variants of VEGF have been described that arise by alternative mRNA splicing. It has been speculated that VEGF may function as a tumor angiogenesis factor in vivo because the expression pattern of VEGF is consistent with a role in embryonic angiogenesis. VEGF mRNA is formed in some primary tumors, VEGF is produced by tumor cell lines in vitro and VEGF mitogenic activity appears to be restricted to endothelial cells. A member of the PDGF receptor family, Flt, has been identified as a high-affinity receptor for VEGF. This clone recognizes proteins of 19-22 kDa (reducing) and 38-44 kDa (non-reducing), identified as various isoforms of VEGF or Vascular Permeability Factor (VEGF/VPF). (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
VEGF/VEGFA [VG1]
Description VEGF is a dimeric glycoprotein with structural homology to PDGF. Several variants of VEGF have been described that arise by alternative mRNA splicing. It has been speculated that VEGF may function as a tumor angiogenesis factor in vivo because the expression pattern of VEGF is consistent with a role in embryonic angiogenesis. VEGF mRNA is formed in some primary tumors, VEGF is produced by tumor cell lines in vitro and VEGF mitogenic activity appears to be restricted to endothelial cells. A member of the PDGF receptor family, Flt, has been identified as a high-affinity receptor for VEGF. This clone recognizes proteins of 19-22 kDa (reducing) and 38-44 kDa (non-reducing), identified as various isoforms of VEGF or Vascular Permeability Factor (VEGF/VPF). (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
YAP [63.7]
Description The Yes-associated protein, otherwise known as YAP, is a 14-3-3 binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3 binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytosketeton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
YAP [63.7]
Description The Yes-associated protein, otherwise known as YAP, is a 14-3-3 binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3 binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytosketeton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Monoclonal antibody to human IFN-gamma (clone MD-1)
Description The monoclonal antibody to human IFN-γ (clone MD-1) was first described in 1985. It has shown to neutralize the antiviral activity of both natural and recombinant human IFN-γ and in a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-1 antibody has been descripted as useful in a sandwich ELISA and in ELISPOT assays. Further, the antibody has proven to cross react with chimpanzee and rhesus macaque IFN-γ and can be used for immunohistochemical staining of frozen tissues. The MD-1 antibody has been reported for use in intracellular flow cytometric analysis and in Luminex systems. Other available formats: biotin labeled (cat. no. CT218) and FITC labeled (cat. no. CT220). (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Chimpanzee,Rhesus Macaque
0 0.5 mg more info 8 days
€325,00 Add to cart -
Monoclonal antibody to human IFN-gamma biotin (clone MD-1)
Description The monoclonal antibody to human IFN-γ was first described in 1985. It has shown to neutralize the antiviral activity of both natural and recombinant human IFN-γ and in a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-1 antibody has been descripted as useful in a sandwich ELISA. Further, the antibody has proven to cross react with rhesus macaque IFN-γ and can be used for immunohistochemical staining of frozen tissues. The MD-1 antibody has been reported for use in intracellular flow cytometric analysis. Other available formats: unconjugated (cat. no. CT215) and FITC labeled (cat. no. CT220). (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Flow cytometry (FC) Reactivity Chimpanzee,Rhesus Macaque Conjugate Biotin
0 0.5 mg more info 8 days
€405,00 Add to cart -
Monoclonal antibody to human IFN-gamma (clone MD-2)
Description The monoclonal antibody to human IFN-γ (clone MD-2) was first described in 1985. It has shown to binds with high affinity to both natural and recombinant human IFN-γ but does not neutralize the antiviral bioactivity of IFN-γ in vitro. In a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-2 antibody has been descripted as useful in a sandwich ELISA. Further, the antibody has proven to cross react with rhesus macaque, cynomolgus monkey and marmoset IFN-γ and can be used for immunohistochemical staining of frozen tissues. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Immunohistochemistry on frozen sections (IHC-Fs),Western Blot (WB) Reactivity Rhesus Macaque,Cynomolgus Monkey,Marmoset
0 mg more info 8 days
€300,00 Add to cart -
Monoclonal antibody to monkey IFN-gamma (clone MD-1)
Description The neutralizing monoclonal antibody to monkey IFN-γ (clone MD-1) was first described in 1985. The MD-1 antibody can be used in a sandwich ELISA and in ELISPOT assays. Further, the antibody has been descripted in immunohistochemical staining of frozen tissues of marmosets and in intracellular flow cytometric analysis. The MD-1 antibody has been reported to cross react with rhesus macaque, pig-tailed macaque, cynomogus monkey, baboon and African green monkey IFN-γ and can be used in Luminex systems. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Rhesus Macaque,Cynomolgus Monkey,Pig-tailed Macaque,Japanese Macaque,Crested Black Macaque,Barbary Macaque,Lion-tailed Macaque,Baboon,Mandrill,African Green Monkey (Chlorocebus),Black Mangabey
0 mg more info 8 days
€325,00 Add to cart
