You are here
-
Pgp9.5/UCHL1 [31A3]
Description Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells, it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK PGP 9.5 has been demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine) 
1 ml more info 
14 days 
€361,40 Add to cart -
Pgp9.5/UCHL1 [31A3]
Description Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells, it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK PGP 9.5 has been demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine)
7 ml more info 14 days
€187,20 Add to cart -
PolyQ/Polyglutamine-Expansion Diseases Marker [5TF1-1C2]
Description Polyglutamine tract are portions of a protein consisting of a sequence of several glutamine unit. Several inheritable neurodegenerative disorders, so-called polyglutamine diseases, occur if a mutation causes a polyglutamine tract in a specific gene to become too long. Important examples of polyglutamine diseases include Huntington's disease, dentatorubralpallidoluysian atrophy (DRPLA), spinobulbar muscular atrophy (SBMA) and types of spinocerebellar ataxia (SCA). In these diseases, the pathogenic alleles usually contain 39 or more consecutive glutamine repeats. Higher repeat numbers lead to lower ages of onset. Patients with 40-60 glutamine repeats normally develop disease as adults, whereas patients with more than 60 repeats develop a juvenile onset disease. Each polyglutamine expansion disorder displays characteristic pathology, with neuronal loss evident in specific regions of the brain. It is believed that cells cannot properly dispose of proteins with overlong polyglutamine tracts Host Mouse Application ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€624,00 Add to cart -
Prostein [A5]
Description PSA, prostate specific antigen, is the classic indicator for transformed pro-state tissue; however, in addition to being upregulated in prostate cancer, PSA is also upregulated in non-malignant conditions, such as benign prostatic hyperplasia. Prostein, also designated Prostate cancer-associated protein 6, is a prostate-specific, 553 amino acid transmembrane protein that is upregulated by androgens. It is considered a marker for prostate cells since it is expressed in all prostatic glandular cells as well as in normal and cancerous prostate tissues. Since it is able to elicit a tumor-directed cytotoxic T cell response, Prostein may be used as a target for the development of PSA- and T cell-based therapeutic strategies for prostate cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
SALL4 [6E3]
Description The Sal-like protein 4, SALL4 is a zinc finger transcription factor located on chromosome 20q13.13-13.2. It is essential during development by maintaining embryonic stem cell pluripotency and self-renewal. Mutations in SALL4 lead to acro-renal-ocular and Okihiro syndromes, a disorder of the eyes and abnormalities of bones in the arms and hands. Recently, SALL4 has been identified as a novel sensitive diagnostic marker for germ cell tumors. Strong SALL4 staining was observed in all seminoma/dysgerminoma/germinomas, embryonal carcinomas, and yolk sac tumors, yielding 100% sensitivity for these malignancies. Compared with _-fetoprotein and glypican-3, SALL4 demonstrated superior sensitivity in detecting yolk sac tumors. Focal SALL4 staining was also observed in choriocarcinomas (66-71%) and teratomas (50-64%). In non-germ cell tumors, SALL4 is expressed in all cases of acute myeloid leukemia, and majority of precursor B-cell acute lymphoblastic lymphomas (79%). In a large immunohistochemi Host Mouse Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€401,70 Add to cart -
SALL4 [6E3]
Description The Sal-like protein 4, SALL4 is a zinc finger transcription factor located on chromosome 20q13.13-13.2. It is essential during development by maintaining embryonic stem cell pluripotency and self-renewal. Mutations in SALL4 lead to acro-renal-ocular and Okihiro syndromes, a disorder of the eyes and abnormalities of bones in the arms and hands. Recently, SALL4 has been identified as a novel sensitive diagnostic marker for germ cell tumors. Strong SALL4 staining was observed in all seminoma/dysgerminoma/germinomas, embryonal carcinomas, and yolk sac tumors, yielding 100% sensitivity for these malignancies. Compared with _-fetoprotein and glypican-3, SALL4 demonstrated superior sensitivity in detecting yolk sac tumors. Focal SALL4 staining was also observed in choriocarcinomas (66-71%) and teratomas (50-64%). In non-germ cell tumors, SALL4 is expressed in all cases of acute myeloid leukemia, and majority of precursor B-cell acute lymphoblastic lymphomas (79%). In a large immunohistochemi Host Mouse Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
Sarcoglycan Alpha/SGCA [F7]
Description The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Sarcoglycan Beta/SGCB [RO17]
Description The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated α-, β-, γ- and δ-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, β- and δ-sarcoglycans are associated with ε-sarcoglycan, a glycoprotein homologous to α-sarcoglycan. Additionally, a complete deficiency in δ-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
SDHB (Succinate Dehydrogenase B) [SDHB/2382]
Description Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. SDH catalyzes the oxidation of succinate to fumarate and transfers electrons to ubiquinone through the coordination of its four subunits (SDHA, SDHB, SDHC, and SDHD). The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. SDH subunit B (SDHB) is ubiquitously expressed in normal tissues. Germline mutations in SDHB, SDHC, or SDHD genes predispose development of phaeochromocytoma, paraganglioma and gastrointestinal stromal tumor (GIST). SDHB immunohistochemistry is helpful in the identification of phaeochromocytomas, paragangliomas or GIST with SDHB mutation. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
SDHB (Succinate Dehydrogenase B) [SDHB/2382]
Description Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. SDH catalyzes the oxidation of succinate to fumarate and transfers electrons to ubiquinone through the coordination of its four subunits (SDHA, SDHB, SDHC, and SDHD). The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. SDH subunit B (SDHB) is ubiquitously expressed in normal tissues. Germline mutations in SDHB, SDHC, or SDHD genes predispose development of phaeochromocytoma, paraganglioma and gastrointestinal stromal tumor (GIST). SDHB immunohistochemistry is helpful in the identification of phaeochromocytomas, paragangliomas or GIST with SDHB mutation. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
