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Napsin A [MD46]
Description Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. In normal tissue, Anti-Napsin A specifically labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is strongly positive in over 80% of primary lung adenocarcinomas and 79% of renal cell carcinoma by immunohistochemistry. Napsin A is a useful marker for lung adenocarcinoma. The combined use of Napsin A and thyroid transcription factor (TTF) improves the sensitivity and specificity for identification of pulmonary adenocarcinoma (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
1 ml more info 14 days
€494,00 Add to cart -
NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
Nerve Growth Factor Receptor (NGFR)/p75 [NGFR5+NTR/912]
Description NGFR, also known as p75NTR, is a receptor of neurotrophins and involved in survival, differentiation and apoptosis of neuron. It is expressed in neuronal cells in various tissues and tumors with neuronal origin. Recent studies suggested that NGFR is also expressed in melanocytes, myoepithelial cells, basal-like cells, perivascular cells and lymphoid dendritic cells. NGFR is helpful in identification of perineural invasion of malignant skin tumors with a panel of antibodies. It is also a complementary marker to S-100 for identification of desmoplastic melanomas. In addition, NGFR maybe used in identifying myoepithelial or basal-like cell differentiation in breast cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Nerve Growth Factor Receptor (NGFR)/p75 [NGFR5+NTR/912]
Description NGFR, also known as p75NTR, is a receptor of neurotrophins and involved in survival, differentiation and apoptosis of neuron. It is expressed in neuronal cells in various tissues and tumors with neuronal origin. Recent studies suggested that NGFR is also expressed in melanocytes, myoepithelial cells, basal-like cells, perivascular cells and lymphoid dendritic cells. NGFR is helpful in identification of perineural invasion of malignant skin tumors with a panel of antibodies. It is also a complementary marker to S-100 for identification of desmoplastic melanomas. In addition, NGFR maybe used in identifying myoepithelial or basal-like cell differentiation in breast cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Nestin [NES/2911]
Description Nestin is a class VI intermediate filament involved in cytoskeletal formation. Nestin facilitates processes of cellular rearrangement such as migration and mitosis, which are characteristics of undifferentiated cells. Nestin was first identified in the nervous system present in mitotically active central and peripheral progenitor cells that developed into neurons and glia during early neurogenesis. Studies have shown that Nestin is expressed in proliferating endothelial cells, thus, may serve as an important marker for angiogenesis. Nestin expression has been reported in melanoma and a wide variety of brain tumors including schwannomas and gliomas. Nestin expression in glioma can be indicative of tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Nestin [NES/2911]
Description Nestin is a class VI intermediate filament involved in cytoskeletal formation. Nestin facilitates processes of cellular rearrangement such as migration and mitosis, which are characteristics of undifferentiated cells. Nestin was first identified in the nervous system present in mitotically active central and peripheral progenitor cells that developed into neurons and glia during early neurogenesis. Studies have shown that Nestin is expressed in proliferating endothelial cells, thus, may serve as an important marker for angiogenesis. Nestin expression has been reported in melanoma and a wide variety of brain tumors including schwannomas and gliomas. Nestin expression in glioma can be indicative of tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Netrin 1 Polyclonal
Description Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
1 ml more info 14 days
€520,00 Add to cart -
NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog
1 ml more info 14 days
€442,00 Add to cart -
NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog
7 ml more info 14 days
€254,80 Add to cart
