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LOXL2 Polyclonal
Description Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2 Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€494,00 Add to cart -
LOXL2 Polyclonal
Description Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2 Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€247,00 Add to cart -
Nanog [MD204R]
Description Nanog is a homeodomain-containing transcription factor that is involved in the maintenance of pluripotency and self renewal in embryonic stem cells. Nanog expression is controlled by a network of factors including Sox2 and the key pluripotency regulator Oct-4. Recent advances in somatic cell reprogramming have utilized viral expression of combinations of transcription factors including nanog, Oct-4, Sox2, KLF4, c-Myc, and LIN28. Studies show that Nanog expression can be absent in normal adult organ tissues, but presented in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma. Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 14 days
€520,00 Add to cart -
Nanog [MD204R]
Description Nanog is a homeodomain-containing transcription factor that is involved in the maintenance of pluripotency and self renewal in embryonic stem cells. Nanog expression is controlled by a network of factors including Sox2 and the key pluripotency regulator Oct-4. Recent advances in somatic cell reprogramming have utilized viral expression of combinations of transcription factors including nanog, Oct-4, Sox2, KLF4, c-Myc, and LIN28. Studies show that Nanog expression can be absent in normal adult organ tissues, but presented in undifferentiated germ cell tumors such as seminoma, dysgerminoma and embryonal carcinoma. Nanog may be used as an aid in the determination of undifferentiated tumors of germ cell origin from non-germ cell tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
1 ml more info 14 days
€507,00 Add to cart -
TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart
