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Synuclein Alpha [MD23R]
Description Alpha-Synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic Parkinson disease. Alpha-Synuclein is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals. The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€260,00 Add to cart -
Tau Phosphorylated Ser396/p-Tau S396 [EPR2731]
Description Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer’s disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€845,00 Add to cart -
Tau Phosphorylated Ser396/p-Tau S396 [EPR2731]
Description Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer’s disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€377,00 Add to cart -
T-bet/TBX21 [MD40R]
Description T-box transcription factor TBX21, also known as T-bet, is a member of the T-box family of transcription factors. It has been confirmed that TBX21 is the key lineage-defining transcription factor that directs the development Th1 cells and is directly responsible for the transactivation of the interferon-γ (IFN-γ) gene. TBX21 is expressed in CD4+ T lymphocytes in normal tissues. In lymphoid malignancies, TBX21 has been found in a subset of T-cell lymphomas with Th1 T-cell differentiation, a subset of B-cell or T cells, non-Hodgkin's lymphomas, majority of Hodgkin's lymphomas and precursor B-cell lymphoblastic leukemia/lymphoblastic lymphomas. However, TBX21 is not expressed in diffuse large B-cell lymphoma and most cases of anaplastic large cell lymphoma. TBX21 is a useful new marker for Hodgkin's lymphoma. TBX21 is also helpful in identification of hairy cell leukemia (HCL). Ventana/Cell Marque have. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
T-bet/TBX21 [MD40R]
Description T-box transcription factor TBX21, also known as T-bet, is a member of the T-box family of transcription factors. It has been confirmed that TBX21 is the key lineage-defining transcription factor that directs the development Th1 cells and is directly responsible for the transactivation of the interferon-γ (IFN-γ) gene. TBX21 is expressed in CD4+ T lymphocytes in normal tissues. In lymphoid malignancies, TBX21 has been found in a subset of T-cell lymphomas with Th1 T-cell differentiation, a subset of B-cell or T cells, non-Hodgkin's lymphomas, majority of Hodgkin's lymphomas and precursor B-cell lymphoblastic leukemia/lymphoblastic lymphomas. However, TBX21 is not expressed in diffuse large B-cell lymphoma and most cases of anaplastic large cell lymphoma. TBX21 is a useful new marker for Hodgkin's lymphoma. TBX21 is also helpful in identification of hairy cell leukemia (HCL). Ventana/Cell Marque have. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
TCL1 [MD117R]
Description T-cell leukemia/lymphoma protein 1A (TCL1) is a member of the TCL1 family and enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1 promotes the nuclear translocation of AKT1 and enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. The expression of TCL1 is restricted to lymphoid cells. It is expressed early in lymphocyte differentiation. Strong expression of TCL1 is found in a subset of mantle zone B lymphocytes and is expressed to a lesser extent by follicle center cells. In B cell neoplasia, TCL1 immunoreactivity is found in the majority of B cell lymphomas including lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (60%), and primary cutaneous B cell lymphoma (55%). The expression of the TCL1 gene characterizes low-grade B cell lymphomas. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
TFE3 [EP285]
Description Xp11 translocation renal cell carcinoma (RCC) is a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus. Xp11 translocation RCC represents the most common type of RCC in children, but is less frequent on a percentage basis in adults. Morphologically, the neoplasm frequently shows papillary architecture and clear cytoplasm, and frequently has associated psammoma bodies. Immunohistochemically, the neoplasm under-expresses epithelial markers such as cytokeratin and epithelial membrane antigen compared with typical RCC. The most sensitive and specific immunohistochemical marker for the Xp11 translocation RCC is nuclear labeling of TFE3 protein, which reflects over-expression of the resulting fusion proteins relative to TFE3. Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma which affects predominantly young patients, Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
TFF1/pS2 [MD119R]
Description Trefoil factor 1 (TFF1), a member of the trefoil factor family, also known as protein pS2 or breast cancer estrogen-inducible protein, is a stabilizer of the mucus gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract. The TFF1 antibody labels gastric mucosal cells, goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, epithelial cells lining the exocrine pancreatic ducts and breast epithelial cells. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€442,00 Add to cart -
TFF1/pS2 [MD119R]
Description Trefoil factor 1 (TFF1), a member of the trefoil factor family, also known as protein pS2 or breast cancer estrogen-inducible protein, is a stabilizer of the mucus gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract. The TFF1 antibody labels gastric mucosal cells, goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, epithelial cells lining the exocrine pancreatic ducts and breast epithelial cells. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
TFF3 [EPR3974]
Description refoil factors (TFFs) constitute a family of mucin-associated peptides containing one or more structurally characteristic trefoil domains. Trefoil factor 3 (TFF3) is a member of the trefoil family. They are mainly synthesized and secreted by mucin secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins. TFF3 is expressed in goblet cells of the intestines and colon, eptihelial cells of the breast, prostate, thyroid, salivary gland and urinary tract. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart
