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PRAME [MD145R]
Description PRAME (preferentially expressed antigen in melanoma) is overexpressed in malignant cells, including primary and metastatic melanomas, acute and chronic leukaemias, Hodgkin’s lymphoma, breast cancer and head and neck squamous cell carcinomas. In AML (acute myeloid leukemia), high levels of PRAME are associated with lower relapse rate and high chances of disease-free survival. PRAME also plays a role in the retinol pathway. It modulates the metabolism of all-trans retinol (vitamin A) and its active metabolites, referred to as retinoids. It is a repressor of retinoic acid receptor signaling. Studies suggest that PRAME expression may be valuable for margin assessment of a known PRAME-positive melanoma, but its expression in nevi, solar lentigines, and benign nonlesional skin can represent a challenge. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€247,00 Add to cart -
Prolactin [MD140R]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Prolactin [MD140R]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
PSA (Prostate Specific Antigen) [KLK3/2871R]
Description Prostate-specific antigen (PSA) is a serine protease member of the human glandular kallikrein family. It is synthesized in the prostate ductal and acinar epithelium and diffused into serum. It is found in normal, hyperplastic, and malignant prostate tissue. Low expression of PSA has been reported in other normal or tumor tissues such as urethral, periurethral, and perianal glands, salivary duct carcinoma, and rare mammary carcinomas. Although low PSA expression has been found in other tissues, PSA is still a specific and sensitive marker for immunohistochemical analysis of tumors with prostate epithelial cell differentiation. It is valuable in the identification of metastatic tumors of prostatic origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€390,00 Add to cart -
PSA (Prostate Specific Antigen) [KLK3/2871R]
Description Prostate-specific antigen (PSA) is a serine protease member of the human glandular kallikrein family. It is synthesized in the prostate ductal and acinar epithelium and diffused into serum. It is found in normal, hyperplastic, and malignant prostate tissue. Low expression of PSA has been reported in other normal or tumor tissues such as urethral, periurethral, and perianal glands, salivary duct carcinoma, and rare mammary carcinomas. Although low PSA expression has been found in other tissues, PSA is still a specific and sensitive marker for immunohistochemical analysis of tumors with prostate epithelial cell differentiation. It is valuable in the identification of metastatic tumors of prostatic origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€214,50 Add to cart -
PSAP (Prostatic or Prostate Specific Acid Phosphatase) [EPR4067]
Description Prostatic Acid Phosphatase (PAP), a member of the histidine acid phosphatase family, is an enzyme that is a major component of prostatic fluid and secreted by the epithelial cells of the prostate gland. PAP labels normal prostate epithelial cells, hyperplastic and cancer cells of prostate. It is helpful in identification of tumors with prostate origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€464,10 Add to cart -
PSAP (Prostatic or Prostate Specific Acid Phosphatase) [EPR4067]
Description Prostatic Acid Phosphatase (PAP), a member of the histidine acid phosphatase family, is an enzyme that is a major component of prostatic fluid and secreted by the epithelial cells of the prostate gland. PAP labels normal prostate epithelial cells, hyperplastic and cancer cells of prostate. It is helpful in identification of tumors with prostate origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
PSMA [MD105R]
Description Prostate-specific membrane antigen (PSMA), also known as folate hydrolase 1(FOLH1), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase Anti-PSMA labels normal prostate epithelial cells and prostate tumor cells. Although the expression of PSMA in neovasculature of a variety of solid tumors has been reported, PSMA expression is highly restricted to the prostate. It is a useful marker for prostate tumors. In prostate cancer, overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, and advanced tumor stage. It can be used as an effective predictor for tumor progression in prostate cancer (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
PSMA [MD105R]
Description Prostate-specific membrane antigen (PSMA), also known as folate hydrolase 1(FOLH1), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase Anti-PSMA labels normal prostate epithelial cells and prostate tumor cells. Although the expression of PSMA in neovasculature of a variety of solid tumors has been reported, PSMA expression is highly restricted to the prostate. It is a useful marker for prostate tumors. In prostate cancer, overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, and advanced tumor stage. It can be used as an effective predictor for tumor progression in prostate cancer (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
ROS [MD15R]
Description ROS or ROS1, a 263914 Da cell membrane tyrosine kinase expressed in brain, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS is undefined, it has been shown to play an important role in differentiation of epididymal epithe. The first oncogenic fusion of ROS, FIG-ROS1, was initially identified by research studies in glioblast, and subsequent studies have found this fusion in cholangiocarcinoa, ovarian can and non-small cell lung cancer (NSCLC). Investigators have found additional oncogenic ROS fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A. ROS fusion proteins activate the SHP-2 phosphatase, P Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart
