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CD69 Polyclonal
Description CD69 is also known as activation-induced molecule (AIM), early activation antigen (EA-1), very early activation antigen (VEA), C-type lectin domain family 2 member C (CLEC2C), MLR-3, GP32/28 and Leu-23. CD69 is a transmembrane type II homodimer receptor. CD69 is comprised of disulfide-linked, differentially glycosylated core protein subunits that are approximately 28 and 34 kDa in size. Each subunit contains a C-type lectin domain. CD69 is expressed on activated T, B, and natural killer (NK) lymphocytes, thymocytes, neutrophils, eosinophils and platelets. In normal peripheral blood, a small and variable percentage of lymphocytes typically express detectable membrane CD69 antigen. Upon activation, CD69 antigen expression increases on lymphocytes. Peak CD69 expression generally occurs within 18 hours of activation, preceding the appearance of HLA-DR, IL-2Rα (CD25) and transferrin receptor (CD71). CD69 is highly expressed on the bright CD3+ subset of thymocytes. FN50 monoclonal antibody l Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog 
1 ml more info 
14 days 
€401,70 Add to cart -
CD69 Polyclonal
Description CD69 is also known as activation-induced molecule (AIM), early activation antigen (EA-1), very early activation antigen (VEA), C-type lectin domain family 2 member C (CLEC2C), MLR-3, GP32/28 and Leu-23. CD69 is a transmembrane type II homodimer receptor. CD69 is comprised of disulfide-linked, differentially glycosylated core protein subunits that are approximately 28 and 34 kDa in size. Each subunit contains a C-type lectin domain. CD69 is expressed on activated T, B, and natural killer (NK) lymphocytes, thymocytes, neutrophils, eosinophils and platelets. In normal peripheral blood, a small and variable percentage of lymphocytes typically express detectable membrane CD69 antigen. Upon activation, CD69 antigen expression increases on lymphocytes. Peak CD69 expression generally occurs within 18 hours of activation, preceding the appearance of HLA-DR, IL-2Rα (CD25) and transferrin receptor (CD71). CD69 is highly expressed on the bright CD3+ subset of thymocytes. FN50 monoclonal antibody l Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€174,20 Add to cart -
CD73/NT5E [D7F9A]
Description Ecto-5’-nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored, membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleosides. NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine monophosphate, which drives the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors. Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promoter leads to upregulation of NT5E during hypoxia (3). The biological roles of NT5E include lymphocyte adhesion, fibrosis (6), and the regulation of nociception. NT5E/CD73 (D7F9A) Rabbit mAb recognizes endogenous levels of total NT5E/CD73 protein (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€494,00 Add to cart -
CD73/NT5E [D7F9A]
Description Ecto-5’-nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored, membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleosides. NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine monophosphate, which drives the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors. Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promoter leads to upregulation of NT5E during hypoxia (3). The biological roles of NT5E include lymphocyte adhesion, fibrosis (6), and the regulation of nociception. NT5E/CD73 (D7F9A) Rabbit mAb recognizes endogenous levels of total NT5E/CD73 protein (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€267,80 Add to cart -
Cereblon/CRBN Polyclonal
Description Cereblon or CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. Cereblon functions energy metabolism, learning and memory. Cereblon acts as a protease in mitochondria and regulates the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding Cereblon belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the Cereblon gene are associated with mild mental retardation. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€494,00 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€163,80 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€464,10 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€254,80 Add to cart -
Claudin 8 [EPR12680(2)]
Description Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast. Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly wo Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€520,00 Add to cart
