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Transcription Factor PU.1/PU.1/Spi1 [EP18]
Description PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development. PU.1 stains B lymphocytes in germinal center and mantle B cells, but not plasma cells. It labels many types of B-cell lymphomas including mantle cell lymphoma, but is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lymphoproliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€254,80 Add to cart -
TTF2/FOXE1 Polyclonal
Description Probable transcription factor. Could be involved in thyroid gland organogenesis. Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse 
1 ml more info 14 days
€455,00 Add to cart -
TTF2/FOXE1 Polyclonal
Description Probable transcription factor. Could be involved in thyroid gland organogenesis. Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€254,80 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian
1 ml more info 14 days
€374,40 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian
7 ml more info 14 days
€174,20 Add to cart -
Uroplakin II [EPR18799]
Description Uroplakin II is a 15 kDa protein component of urothelial plaques. Studies have shown Uroplakin II mRNA was highly specific and was expressed in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial carcinoma of the bladder. Uroplakin II is a highly specific and may be useful in identifying tumors of urothelial origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
Uroplakin II [EPR18799]
Description Uroplakin II is a 15 kDa protein component of urothelial plaques. Studies have shown Uroplakin II mRNA was highly specific and was expressed in both bladder cancer tissues and peripheral blood of patients with primary and metastatic urothelial carcinoma of the bladder. Uroplakin II is a highly specific and may be useful in identifying tumors of urothelial origin. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€247,00 Add to cart -
Uroplakin III [EPR14420]
Description Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16 nm crystalline particles. Moll et al. reported that UPIII was detectable immunohistochemically in 29 of 55 primary (53%) and 23 of 35 metastatic (66%) urothelial carcinomas, whereas many non- urothelial carcinomas were UPIII-negative. The authors concluded that anti-UPIII should be a valuable marker, especially for the specific identification of urothelial carcinomas in patients with metastases of unknown primary site. Subsequently, Olsburgh et al. studied UP gene expression in normal urothelium and bladder cancer specimens, and found that expression was absent after malignant transformation. Ohtsuka et al. concluded in their studies that UPIII expression was strongly associated with lower tumor Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
Uroplakin III [EPR14420]
Description Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16 nm crystalline particles. Moll et al. reported that UPIII was detectable immunohistochemically in 29 of 55 primary (53%) and 23 of 35 metastatic (66%) urothelial carcinomas, whereas many non- urothelial carcinomas were UPIII-negative. The authors concluded that anti-UPIII should be a valuable marker, especially for the specific identification of urothelial carcinomas in patients with metastases of unknown primary site. Subsequently, Olsburgh et al. studied UP gene expression in normal urothelium and bladder cancer specimens, and found that expression was absent after malignant transformation. Ohtsuka et al. concluded in their studies that UPIII expression was strongly associated with lower tumor Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€247,00 Add to cart -
USP6NL/RNTRE Polyclonal
Description Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€520,00 Add to cart
