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Cytokeratin 18 [MD92R]
Description Cytokeratin 18 (CK18) is intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells but not in stratified epithelial cells. CK18 is often co-expressed with CK8. CK8/18 is the major keratin pair in simple-type epithelia. Adenocarcinomas originated from simple and glandular epithelium showed CK18 positive staining. In squamous carcinoma, poorly differentiated tumor cells show CK18 reactivity. Loss of CK 18 expression is associated with progression of breast carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€401,70 Add to cart -
Cytokeratin 18 [MD92R]
Description Cytokeratin 18 (CK18) is intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells but not in stratified epithelial cells. CK18 is often co-expressed with CK8. CK8/18 is the major keratin pair in simple-type epithelia. Adenocarcinomas originated from simple and glandular epithelium showed CK18 positive staining. In squamous carcinoma, poorly differentiated tumor cells show CK18 reactivity. Loss of CK 18 expression is associated with progression of breast carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
Cytokeratin 19 [MD93R]
Description Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. CK19 is synthesized mainly in embryonic and adult simple epithelia, but has also been found in non-keratinizing stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is different from other keratin-encoding genes. CK19 antibody is a useful tool for the identification of epithelial tumors. It is helpful in distinguishing hepatocellular carcinoma (CK19-) from cholangiocarcinoma (CK19+) or metastatic carcinoma in liver (CK19+). (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Cytokeratin 19 [MD93R]
Description Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. CK19 is synthesized mainly in embryonic and adult simple epithelia, but has also been found in non-keratinizing stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is different from other keratin-encoding genes. CK19 antibody is a useful tool for the identification of epithelial tumors. It is helpful in distinguishing hepatocellular carcinoma (CK19-) from cholangiocarcinoma (CK19+) or metastatic carcinoma in liver (CK19+). (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
Cytokeratin 5 [EP24]
Description Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10% to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK5 and its corresponding partner, type I keratin CK14, both of which are essential for the formation of 8-nm filaments. CK5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin. CK5 labels myoepithelial cells of breast and prostate basal cells. A cocktail of CK5, CK14 and p63, has been used as sensitive and specific basal cell marker of basal-like phenotype of breast carcinoma and to differentiate normal and prostate cancer. Loss-of-function mutations in the keratin 5 gene Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€464,10 Add to cart -
Cytokeratin 5 [EP24]
Description Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10% to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK5 and its corresponding partner, type I keratin CK14, both of which are essential for the formation of 8-nm filaments. CK5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin. CK5 labels myoepithelial cells of breast and prostate basal cells. A cocktail of CK5, CK14 and p63, has been used as sensitive and specific basal cell marker of basal-like phenotype of breast carcinoma and to differentiate normal and prostate cancer. Loss-of-function mutations in the keratin 5 gene Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
DAZL/SPGYLA/TPX2 Polyclonal
Description DAZL (Deleted in azoospermia-like 1; SPGY-like-autosomal) is an RNA-binding protein that interacts with mRNA transcripts by its N-terminal RNA recognition motifs. It is the product of the Y-linked DAZ gene, and is found exclusively in the testes. DAZL regulates gene expression during spermatogenesis and may shuttle between the nucleus and cytoplasm during various stages of this process. It interacts with other proteins of the DAZ family via its DAZ-like domain, including DAZ, BOLL, DAZAP1, DAZAP2, and PUM2. Disruption of DAZL expression may play a role in male infertility. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Bovine 
1 ml more info 14 days
€494,00 Add to cart -
DEFB1/Beta-defensin 1 Polyclonal
Description Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. The mature form of Beta-defensin 1 is 36 amino acids. Beta-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. Research indicates that human Beta-defensin 1 may contribute to the antimicrobial activity of airway surface fluid and may play a role in the mucosal defenses of the lung. Human β-defensin 1 shares homology with other Beta-defensins from human blood filtrate and is also Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€455,00 Add to cart -
Desmin [MD97R]
Description Desmin is a characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle) and neoplasms associated with them. In general, desmin is a specific marker for myogenic differentiation among soft tissue tumors. It is seen in the majority of rhadbomyomas,leiomyomas, rhadbomyosarcoma, and leiomyosarcomas. Desmin is also seen in myofibroblasts. Myoepithelial cells typically lack desmin. The antibody labels smooth and striated muscle cells as well as mesothelial cells. It allows the subtyping of many undifferentiated and pleomorphic tumors through intermediate filament analysis. With selected panels of antibodies, it is a useful tool to separate the different pleomorphic spindle cell tumors and round cell tumors in soft tissues and skin. The antibody labels strongly reactive mesothelial cells, but not malignant mesothelioma and adenocarcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€468,00 Add to cart -
Desmin [MD97R]
Description Desmin is a characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle) and neoplasms associated with them. In general, desmin is a specific marker for myogenic differentiation among soft tissue tumors. It is seen in the majority of rhadbomyomas,leiomyomas, rhadbomyosarcoma, and leiomyosarcomas. Desmin is also seen in myofibroblasts. Myoepithelial cells typically lack desmin. The antibody labels smooth and striated muscle cells as well as mesothelial cells. It allows the subtyping of many undifferentiated and pleomorphic tumors through intermediate filament analysis. With selected panels of antibodies, it is a useful tool to separate the different pleomorphic spindle cell tumors and round cell tumors in soft tissues and skin. The antibody labels strongly reactive mesothelial cells, but not malignant mesothelioma and adenocarcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart
