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Napsin A [MD46]
Description Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. In normal tissue, Anti-Napsin A specifically labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is strongly positive in over 80% of primary lung adenocarcinomas and 79% of renal cell carcinoma by immunohistochemistry. Napsin A is a useful marker for lung adenocarcinoma. The combined use of Napsin A and thyroid transcription factor (TTF) improves the sensitivity and specificity for identification of pulmonary adenocarcinoma (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
Napsin A [MD46]
Description Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. In normal tissue, Anti-Napsin A specifically labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is strongly positive in over 80% of primary lung adenocarcinomas and 79% of renal cell carcinoma by immunohistochemistry. Napsin A is a useful marker for lung adenocarcinoma. The combined use of Napsin A and thyroid transcription factor (TTF) improves the sensitivity and specificity for identification of pulmonary adenocarcinoma (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
Napsin A [NAPSA/3308]
Description Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. In normal tissue, Anti-Napsin A specifically labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is strongly positive in over 80% of primary lung adenocarcinomas and 79% of renal cell carcinoma by immunohistochemistry. Napsin A is a useful marker for lung adenocarcinoma. The combined use of Napsin A and thyroid transcription factor (TTF) improves the sensitivity and specificity for identification of pulmonary adenocarcinoma (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
Napsin A [NAPSA/3308]
Description Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. In normal tissue, Anti-Napsin A specifically labels type II pneumocytes in adult lung and epithelial cells in kidney tissues. In abnormal tissues, Napsin A is strongly positive in over 80% of primary lung adenocarcinomas and 79% of renal cell carcinoma by immunohistochemistry. Napsin A is a useful marker for lung adenocarcinoma. The combined use of Napsin A and thyroid transcription factor (TTF) improves the sensitivity and specificity for identification of pulmonary adenocarcinoma (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
Neogenin 1/NEO1 [MD160]
Description Neogenin (NEO1) is a type I transmembrane protein that is crucial for axonal guidance and neuronal migration. It is also involved in regulating differentiation programs in many embryonic and adult tissues. It is a member of the immunoglobulin (Ig) superfamily and is closely related to deleted in colorectal cancer (DCC). NEO and DCC, together with the UNC5 family of type I transmembrane proteins, are receptors for the netrin/UNC6 family of laminin-related bifunctional guidance molecules that both attract some axons and repel others. In mouse, at least five netrins (netrin‑1, ‑3, -4, G1, and G2) have been identified. Mouse netrin-1 and netrin-3 have been shown to be ligands for mouse NEO. Neogenin protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coi Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
Nerve Growth Factor Receptor (NGFR)/p75 [NGFR5+NTR/912]
Description NGFR, also known as p75NTR, is a receptor of neurotrophins and involved in survival, differentiation and apoptosis of neuron. It is expressed in neuronal cells in various tissues and tumors with neuronal origin. Recent studies suggested that NGFR is also expressed in melanocytes, myoepithelial cells, basal-like cells, perivascular cells and lymphoid dendritic cells. NGFR is helpful in identification of perineural invasion of malignant skin tumors with a panel of antibodies. It is also a complementary marker to S-100 for identification of desmoplastic melanomas. In addition, NGFR maybe used in identifying myoepithelial or basal-like cell differentiation in breast cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
Nerve Growth Factor Receptor (NGFR)/p75 [NGFR5+NTR/912]
Description NGFR, also known as p75NTR, is a receptor of neurotrophins and involved in survival, differentiation and apoptosis of neuron. It is expressed in neuronal cells in various tissues and tumors with neuronal origin. Recent studies suggested that NGFR is also expressed in melanocytes, myoepithelial cells, basal-like cells, perivascular cells and lymphoid dendritic cells. NGFR is helpful in identification of perineural invasion of malignant skin tumors with a panel of antibodies. It is also a complementary marker to S-100 for identification of desmoplastic melanomas. In addition, NGFR maybe used in identifying myoepithelial or basal-like cell differentiation in breast cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
Nestin [NES/2911]
Description Nestin is a class VI intermediate filament involved in cytoskeletal formation. Nestin facilitates processes of cellular rearrangement such as migration and mitosis, which are characteristics of undifferentiated cells. Nestin was first identified in the nervous system present in mitotically active central and peripheral progenitor cells that developed into neurons and glia during early neurogenesis. Studies have shown that Nestin is expressed in proliferating endothelial cells, thus, may serve as an important marker for angiogenesis. Nestin expression has been reported in melanoma and a wide variety of brain tumors including schwannomas and gliomas. Nestin expression in glioma can be indicative of tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
Nestin [NES/2911]
Description Nestin is a class VI intermediate filament involved in cytoskeletal formation. Nestin facilitates processes of cellular rearrangement such as migration and mitosis, which are characteristics of undifferentiated cells. Nestin was first identified in the nervous system present in mitotically active central and peripheral progenitor cells that developed into neurons and glia during early neurogenesis. Studies have shown that Nestin is expressed in proliferating endothelial cells, thus, may serve as an important marker for angiogenesis. Nestin expression has been reported in melanoma and a wide variety of brain tumors including schwannomas and gliomas. Nestin expression in glioma can be indicative of tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
NeuN [A60]
Description NeuN antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuro. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists a Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Avian, Chicken, Ferret, Human, Mouse,Pig (Porcine), Rat, Salamander