You are here
-
Luthenizing Hormone-beta (LH-beta) [SPM103]
Description Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule; two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the ante Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Macrophage L1 Protein [MAC387]
Description Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupfferā€™s cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhans's cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Baboon, Monkey, Bovine,Pig (Porcine), Goat, Horse, Cat, Dog (Canine), Rabbit, Guinea Pig, Rat, Mouse
1 ml more info 14 days
€361,40 Add to cart -
Macrophage Specific [LN-5]
Description LN5 stains an unidentified antigen in cytoplasm of macrophages and histiocytes in hematopoietic organs. It stains mantle zone B lymphocytes of the lymph node and spleen, spermatogonia, chief cells of the stomach, ductal epithelium of breast and tubular epithelium of kidney. It is strongly reactive with cases of true histiocytic lymphoma but is negative, except for macrophages, in Hodgkin's disease and non-Hodgkin's lymphomas. It can be an important tool for the study of malignant and benign histiocytic lesions. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Macrophage Specific [LN-5]
Description LN5 stains an unidentified antigen in cytoplasm of macrophages and histiocytes in hematopoietic organs. It stains mantle zone B lymphocytes of the lymph node and spleen, spermatogonia, chief cells of the stomach, ductal epithelium of breast and tubular epithelium of kidney. It is strongly reactive with cases of true histiocytic lymphoma but is negative, except for macrophages, in Hodgkin's disease and non-Hodgkin's lymphomas. It can be an important tool for the study of malignant and benign histiocytic lesions. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MAGE1 [MA454]
Description Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC) Reactivity Human, Rat, Dog
1 ml more info 14 days
€361,40 Add to cart -
MAGE1 [MA454]
Description Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC) Reactivity Human, Rat, Dog
7 ml more info 14 days
€187,20 Add to cart -
Major Vault Protein (MVP) [1032]
Description Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
MALT1 [MLT1/410]
Description Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MALT1 [MLT1/410]
Description Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Mammaglobin [304-1A5]
Description The Mammaglobin gene encodes a 10-kDa glycoprotein that is homolog to human Clara cell 10-kDa protein (CC10)/uteroglobin. SCGB2A2. Expression of the mammaglobin gene is highly restricted to the adult mammary gland. Antibody to Mammaglobin labels normal breast epithelial cells and breast tumor cells. It is a useful marker for identification of primary and metastatic breast cancer. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart
