| Quantity | Title | Price |
|---|---|---|
| 1 × | IARS2 antibody | 0 |
You are here
-
catalase [H9]
Description This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€374,40 Add to cart -
catalase [H9]
Description This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Catenin Beta [15B8]
Description Catenin Beta is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation. Mutations in the Beta-Catenin gene CTNNB1 leading to stabilization of Beta-Catenin in the cytoplasm and translocation to the nucleus have been implicated in various forms of tumor including familial adenomatous polyposis, fibromatosis, solitary fibrous tumors and endometrial carcinoma. A nuclear accumulation of Beta-Catenin in fibromatosis (desmoid tumor) in various locations including breast and mesentery is useful in the differentiation of this tumor from other fibroblast like lesions. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Chicken
1 ml more info 14 days
€374,40 Add to cart -
Catenin Beta [15B8]
Description Catenin Beta is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation. Mutations in the Beta-Catenin gene CTNNB1 leading to stabilization of Beta-Catenin in the cytoplasm and translocation to the nucleus have been implicated in various forms of tumor including familial adenomatous polyposis, fibromatosis, solitary fibrous tumors and endometrial carcinoma. A nuclear accumulation of Beta-Catenin in fibromatosis (desmoid tumor) in various locations including breast and mesentery is useful in the differentiation of this tumor from other fibroblast like lesions. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Chicken
7 ml more info 14 days
€187,20 Add to cart -
Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog
1 ml more info 14 days
€374,40 Add to cart -
Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog
7 ml more info 14 days
€187,20 Add to cart -
Caveolin 1 (CAV1) [6C2B2]
Description Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, α and ß, due to alternate splicing of the mRNA. Caveolin-1 forms large lipid-binding ho Host Mouse Application Bioimg , Immunohistochemistry (IHC) , Immunoprecipitation (IP) , Western Blot (WB) Reactivity Human, Mouse, Rat, Dog (Canine), Rabbit
1 ml more info 14 days
€429,00 Add to cart -
Caveolin 1 (CAV1) [6C2B2]
Description Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, α and ß, due to alternate splicing of the mRNA. Caveolin-1 forms large lipid-binding ho Host Mouse Application Bioimg , Immunohistochemistry (IHC) , Immunoprecipitation (IP) , Western Blot (WB) Reactivity Human, Mouse, Rat, Dog (Canine), Rabbit
7 ml more info 14 days
€254,80 Add to cart -
CD10 [56C6]
Description The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin and substance P. CD10 is expressed by a number of hematopoietic cells such as immature T and B cells, B cells of the germinal centers of lymphoid follicles and granulocytes. It also reacts with a variety of non-hematopoietic cells, including epithelial cells in GI tract and kidney tubular. In liver, the bile canaliculi shows a moderate to strong staining. CD10 has been used for the identification and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis. It is also known to be a marker of endometrial stromal cells. Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Cat, Dog
1 ml more info 14 days
€494,00 Add to cart -
CD10 [56C6]
Description The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin and substance P. CD10 is expressed by a number of hematopoietic cells such as immature T and B cells, B cells of the germinal centers of lymphoid follicles and granulocytes. It also reacts with a variety of non-hematopoietic cells, including epithelial cells in GI tract and kidney tubular. In liver, the bile canaliculi shows a moderate to strong staining. CD10 has been used for the identification and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis. It is also known to be a marker of endometrial stromal cells. Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Cat, Dog
7 ml more info 14 days
€187,20 Add to cart
