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ABCB11/BRIC2/BSEP [MD122]
Description Bile salt export pump (UniProt O95342; also known as ATP-binding cassette sub-family B member 11, Sister of P-glycoprotein) is encoded by the ABCB11 (also known as BRIC2, BSEP, PFIC2, SPGP) gene (Gene ID 8647) in human. Bile is produced by hepatocytes in the liver and released into the biliary system of ducts and gallbladder. After food ingestion, bile is released in the form of mixed micelles of salts and phospholipids into the duodenum where its detergent properties act to solubilize lipids to help their absorption by the intestine. Bile salt export pump is an ATP-binding cassette (ABC) family member localized to the hepatocyte canalicular membrane where it plays an important role in the bile salt-dependent bile flow and the normal enterohepatic circulation of bile salts from the distal intestine back to the liver. ABCB11/BSEP gene mutations are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), benign recurrent intrahepatic cholestasis type 2 (BRIC2), drug Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
ABCG2/BCRP/CD338 [B1]
Description Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
ACTH [2F6]
Description ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).ĀIt also may react with other tumors (e.g. some small cell carcinomas of the lung) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
ACTH [2F6]
Description ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).ĀIt also may react with other tumors (e.g. some small cell carcinomas of the lung) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
ACTH [AH26]
Description ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).ĀIt also may react with other tumors (e.g. some small cell carcinomas of the lung) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
ACTH [AH26]
Description ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).ĀIt also may react with other tumors (e.g. some small cell carcinomas of the lung) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Actin alpha Sarcomeric [5C5]
Description Actin is a cytoskeletal protein that regulates cell motility, secretion, phagocytosis and cytokinesis. The NH2-terminal of actin may function as antigen. This terminal may also modulate actin interactions and may associate with proteins such as myosin. This antibody is specific for α-skeletal and α-cardiac muscle actins as characterized by ELISA, immunoblot and immunohistochemistry. The antibody shows wide species cross reactivity with tissue from human, sheep, bovine, rabbit, guinea pig, rat, frog, snake, and carp. However, it does not react with smooth muscle tissue. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Sheep, Bovine, Rabbit, Guinea Pig, Rat, Frog, Snake, Carp
1 ml more info 14 days
€361,40 Add to cart -
Actin alpha Sarcomeric [5C5]
Description Actin is a cytoskeletal protein that regulates cell motility, secretion, phagocytosis and cytokinesis. The NH2-terminal of actin may function as antigen. This terminal may also modulate actin interactions and may associate with proteins such as myosin. This antibody is specific for α-skeletal and α-cardiac muscle actins as characterized by ELISA, immunoblot and immunohistochemistry. The antibody shows wide species cross reactivity with tissue from human, sheep, bovine, rabbit, guinea pig, rat, frog, snake, and carp. However, it does not react with smooth muscle tissue. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Sheep, Bovine, Rabbit, Guinea Pig, Rat, Frog, Snake, Carp
7 ml more info 14 days
€187,20 Add to cart -
Actin Muscle Specific [HHF35]
Description This antibody recognizes all muscular actin isotypes. It labels myoepithelial, smooth muscle, skeletal, cardiac muscle cells and leiomyomas. It has been reported to react with pericytes and reactive myofibroblasts. Positive staining cells have been reported in some sarcomas, representing either myofibroblasts or pericytes components. Using this antibody with other myogenic markers such as smooth muscle a ctin, desmin and vimentin will be very helpful for differentiation of tumor from muscle origin. Clone HHF35 has been demonstrated to be reliable marker for soft tissue tumors with muscle differentiation, i.e. leiomyomas, leiomyosarcomas, and rhabdomyosarcomas. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Actin Muscle Specific [HHF35]
Description This antibody recognizes all muscular actin isotypes. It labels myoepithelial, smooth muscle, skeletal, cardiac muscle cells and leiomyomas. It has been reported to react with pericytes and reactive myofibroblasts. Positive staining cells have been reported in some sarcomas, representing either myofibroblasts or pericytes components. Using this antibody with other myogenic markers such as smooth muscle a ctin, desmin and vimentin will be very helpful for differentiation of tumor from muscle origin. Clone HHF35 has been demonstrated to be reliable marker for soft tissue tumors with muscle differentiation, i.e. leiomyomas, leiomyosarcomas, and rhabdomyosarcomas. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
