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  • Article number: MC0684
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    CD50 (ICAM-3) [186-2G9]

    Description CD50 (ICAM-3) is a leukocyte-specific surface receptor involved in primary immune responses. It belongs to the immunoglobulin gene superfamily (Igsf). CD50 is constitutively expressed on human leukocytes, such as T and B lymphocytes, monocytes and neutrophils, and localizes to the rear of polarized leukocytes and clusters with the ezrin-radixin-moesin (ERM) proteins moesin and ezrin. These ERM proteins link CD50 to the actin cytoskeleton. It recognizes the Beta 2-integrin leukocyte function associated molecule-1 (LFA-1) as a receptor, moreover it also functions as a ligand for LFA-1, Mac-1 (CD11b/CD8), adb2 integrins, and the Dendritic Cell-Specific ICAM-3-Grabbing Non Integrin (DC-SIGN) C-type lectin. CD50 mediates a plethora of immunologically relevant homotypic and heterotypic intercellular interactions, such as leukocyte recruitment during migration, removal of apoptotic cells and lymphocyte interactions with antigen-presenting cells. Importantly, CD50 is involved in the interactio
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
    Add to cart
  • Article number: MC0684RTU7
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    CD50 (ICAM-3) [186-2G9]

    Description CD50 (ICAM-3) is a leukocyte-specific surface receptor involved in primary immune responses. It belongs to the immunoglobulin gene superfamily (Igsf). CD50 is constitutively expressed on human leukocytes, such as T and B lymphocytes, monocytes and neutrophils, and localizes to the rear of polarized leukocytes and clusters with the ezrin-radixin-moesin (ERM) proteins moesin and ezrin. These ERM proteins link CD50 to the actin cytoskeleton. It recognizes the Beta 2-integrin leukocyte function associated molecule-1 (LFA-1) as a receptor, moreover it also functions as a ligand for LFA-1, Mac-1 (CD11b/CD8), adb2 integrins, and the Dendritic Cell-Specific ICAM-3-Grabbing Non Integrin (DC-SIGN) C-type lectin. CD50 mediates a plethora of immunologically relevant homotypic and heterotypic intercellular interactions, such as leukocyte recruitment during migration, removal of apoptotic cells and lymphocyte interactions with antigen-presenting cells. Importantly, CD50 is involved in the interactio
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €187,20 
    Add to cart
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