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Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
Musashi1 (Msi1) [69-Q]
Description Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Musashi1 (Msi1) [69-Q]
Description Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Musashi2 (Msi2) Polyclonal
Description Musashi 2 (Msi2) protein, a regulator of mRNA translation, was consistently elevated in metastasis-competent cell lines. Msi2 is reported to be a potential oncoprotein in cases of leukemia and several solid tumors. The Msi2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukemia and stem cell function. The Msi2 RNA-binding protein is a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Msi2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinomas, and that Msi2 loss-of-function abrogates colorectal cancer cell growth.Msi2 is highly expressed in human myeloid leukemia (AML) cell lines, and high expression of Msi2 mRNA is associated with decreased survival in AML, suggesting its use as a new prognostic marker. It has been demonstrated that Msi2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valu Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€401,70 Add to cart -
MxA/MX1/IFI78K [M143]
Description Interferon-induced GTP-binding protein Mx1 (UniProt P20591; also known as IFI-78K, Interferon-induced protein p78, Interferon-inducible protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance 1) is encoded by the MX1 (also known as MX, IFI78) gene (Gene ID 4599) in human. The interferon-inducible myxovirus resistance (Mx) proteins belong to the family of large GTPases and are highly homologous with dynamins within their GTP-binding domain. Mx proteins differ from small GTPases and heterotrimeric G proteins in features such as their large size (70–100 kDa), a relatively low affinity for GTP, and a high intrinsic rate of GTP hydrolysis. Mx proteins contain a highly conserved tripartite GTP-binding motif within the N-terminal G domain, while their less conserved C-terminal half serves different functions such as homooligomerization and association with binding partners. Two distinct regions of human MxA, a central interactive Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB), Reactivity Human, Mouse, Rat, Guinea Pig
1 ml more info 14 days
€546,00 Add to cart -
Myeloperoxidase (MPO) Polyclonal
Description Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophil granulocytes (NGs). Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products, which are proposed to contribute to tissue damage during inflammation. MPO is a marker for myeloid cells. It may also be weakly expressed in cells of monocytic origin. It is useful for differentiating acute myelogenous leukemia from acute lymphoblastic leukemia, In addition, MPO is thought to be involved in the pathology Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Myeloperoxidase (MPO) Polyclonal
Description Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophil granulocytes (NGs). Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products, which are proposed to contribute to tissue damage during inflammation. MPO is a marker for myeloid cells. It may also be weakly expressed in cells of monocytic origin. It is useful for differentiating acute myelogenous leukemia from acute lymphoblastic leukemia, In addition, MPO is thought to be involved in the pathology Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
MyoD1 (Rhabdomyosarcoma Marker) [5.8A]
Description Recognizes a phosphor-protein of 45kDa, identified as MyoD1. The epitope of this antibody maps between amino acid 180-189 in the C-terminal of mouse MyoD1 protein. It does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat, Chicken
1 ml more info 14 days
€361,40 Add to cart -
Myoglobin [MB/2105]
Description Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand. Antibody to myoglobin labels skeletal and cardiac muscle cells. In combination with other striated muscle markers such as vimentin and myogenin, myoglobin is helpful in identification of rhabdomyosarcoma and tumors with skeletal muscle differentiation. Recently, myoglobin has been reported to be expressed on epithelial cancer cells due to changed metabolic and environmental conditions. Myoglobin expression on cancer cells may play a causative role in tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Myoglobin [MB/2105]
Description Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand. Antibody to myoglobin labels skeletal and cardiac muscle cells. In combination with other striated muscle markers such as vimentin and myogenin, myoglobin is helpful in identification of rhabdomyosarcoma and tumors with skeletal muscle differentiation. Recently, myoglobin has been reported to be expressed on epithelial cancer cells due to changed metabolic and environmental conditions. Myoglobin expression on cancer cells may play a causative role in tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart
