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Cytokeratin 5/8 [C-50]
Description It reacts with keratin 5 (58kDa) and keratin 8 (52.5kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human,Pig (Porcine), Mouse, Rat, Hamster, Bovine, Dog (Canine), Sheep 
1 ml more info 
14 days 
€361,40 Add to cart -
Cytokeratin Cocktail [AE1&AE3]
Description The antibody cocktail labels simple epithelia and their tumors including cytokeratins expressed in complex stratified squamous epithelia. Positive results aid in the classification of normal and a wide range of neoplastic tissues as epithelial in origin. This antibody serves as first tier antibody for differentiation of undifferentiated neoplasm. Pan Cytokeratin clone AE1/AE3 antibody may be used with a panel of antibodies for differential diagnosis, e.g. Breast vs. lung or liver: CK7, AE1/AE3, CEA, GCDFP-15, TTF-1; Renal vs. lung or liver: AE1/AE3, CEA, TTF-1, Renal Cell Ag; Seminoma vs. lung or liver: CAM5.2, AE1/AE3, PLAP, EMA, CD30; Embryonal germ cell vs. lung or liver: AE1/AE3, TTF-1, CK7, PLAP, CD30. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), (0.5-1ug/million cells), Immunocytochemistry (ICC)/IF (1-2ug/ml), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml 2 hrs RT) Reactivity Human, Mouse, Rat, Rabbit, Monkey, Bovine, Dog (Canine), Chicken
1 ml more info 14 days
€361,40 Add to cart -
Cytokeratin LMW [KRTL/1077]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
Cytokeratin LMW [KRTL/1077]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
Enigma/PDLIM1 [MD100]
Description PDLIM1 (PDZ and LIM domain 1), also known as Enigma, CLIM1, CLP36, or Elfin, is a 329 amino acid cytoplasmic protein that associates with actin stress fibers at the cytoskeleton. This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. Expressed at high levels in skeletal muscle and heart and at lower levels in colon, small intestine, spleen, lung, placenta, kidney, liver, thymus and pancreas, especially PDLIM1 functions as a cytoskeletal protein that is thought to act as an adaptor, bringing target proteins to the cytoskeleton. The protein has a role in cell migration, invasion and metastasis in breast cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
ER-beta [ERb455]
Description Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of r Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Mouse, Rat,Pig (Porcine), Horse, Sheep
1 ml more info 14 days
€361,40 Add to cart -
ER-beta [ERb455]
Description Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of r Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Mouse, Rat,Pig (Porcine), Horse, Sheep
7 ml more info 14 days
€187,20 Add to cart -
ERG [MD188R]
Description ERG, the ETS related gene, belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. This family of transcription factors contains approximately 30 members that share a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) and are thus distinguished in sub-families. The aberrant expression of several ETS proteins is involved in tumor development and progression. ERG belongs to the Erg/Fli-1 sub-family. Its involvement in human cancers has been widely studied. ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of proteins such as metalloprotease-1 (MMP-1) and MMP-3. EWS-ERG, or EWS-Fli-1 fusion, is a characteristic of Ewing’s sarcoma. TMPRSS2-ERG fusion, which occurs on account of transloca Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human Mouse, Rat
1 ml more info 14 days
€416,00 Add to cart -
ERG [MD188R]
Description ERG, the ETS related gene, belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. This family of transcription factors contains approximately 30 members that share a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) and are thus distinguished in sub-families. The aberrant expression of several ETS proteins is involved in tumor development and progression. ERG belongs to the Erg/Fli-1 sub-family. Its involvement in human cancers has been widely studied. ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of proteins such as metalloprotease-1 (MMP-1) and MMP-3. EWS-ERG, or EWS-Fli-1 fusion, is a characteristic of Ewing’s sarcoma. TMPRSS2-ERG fusion, which occurs on account of transloca Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human Mouse, Rat
7 ml more info 14 days
€234,00 Add to cart -
FGF2/BFGF [C2]
Description Fibroblast growth factor-1 (FGF1), also designated acidic FGF, and fibroblast growth factor-2 (FGF2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF3 (Int2) and FGF4 (hst/Kaposi), FGF5, FGF6, FGF7 (KGF), FGF8 (AIGF), FGF9 (GAF) and FGF10-FGF23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart
