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Article number: MF001S

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MedaFluo™ 488 Mouse on Mouse Immunofluorescence Detection Kit

Description	MedaFluo™ 488 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF002M

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Description	MedaFluo™ 550 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF002S

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Description	MedaFluo™ 550 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF003M

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Description	MedaFluo™ 594 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF003S

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Description	MedaFluo™ 594 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF004M

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Description	MedaFluo™ 650 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: MF004S

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Description	MedaFluo™ 650 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Mouse
Reactivity	Mouse

Article number: RC0322

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Description	Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2
Host	Rabbit
Application	Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: RC0322RTU7

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Description	Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2
Host	Rabbit
Application	Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: MC0493

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Description	The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. (Shipping Cost: €200.00)
Host	Mouse
Application	Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat, Sheep, Bovine