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Wilms' Tumor (WT1) [6F-H2]
Description Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumor, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
YAP [63.7]
Description The Yes-associated protein, otherwise known as YAP, is a 14-3-3 binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3 binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytosketeton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
YAP [63.7]
Description The Yes-associated protein, otherwise known as YAP, is a 14-3-3 binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3 binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytosketeton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
DuoFluo™ 488+550 Mouse+Rabbit on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+550 Mouse+Rabbit on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Mouse, Rabbit Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
DuoFluo™ 488+594 Mouse+Rabbit on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+594 Mouse+Rabbit on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Mouse, Rabbit Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
DuoFluo™ 488+650 Mouse+Rabbit on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+650 Mouse+Rabbit on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Mouse, Rabbit Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
DuoFluo™ 488+550 Rabbit+Rat on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+550 Rabbit+Rat on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Rabbit, Rat Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
DuoFluo™ 488+594 Rabbit+Rat on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+594 Rabbit+Rat on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Rabbit, Rat Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
DuoFluo™ 488+650 Rabbit+Rat on Mouse IF Double Staining Detection Kit
Description DuoFluo™ 488+650 Rabbit+Rat on Mouse IF Double Staining Detection Kit (Shipping Cost: €200.00) Host Rabbit, Rat Reactivity Mouse
120 slides more info 14 days
€796,90 Add to cart -
MedaFluo™ 488 Mouse on Mouse Immunofluorescence Detection Kit
Description MedaFluo™ 488 Mouse on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00) Host Mouse Reactivity Mouse
18 ml more info 14 days
€709,80 Add to cart
