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Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€374,40 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€163,80 Add to cart -
Claudin 4 [A12]
Description The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23. Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€361,40 Add to cart -
Claudin 4 [A12]
Description The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23. Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€464,10 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€254,80 Add to cart -
Claudin 8 [EPR12680(2)]
Description Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast. Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly wo Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€520,00 Add to cart -
Claudin 8 [EPR12680(2)]
Description Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast. Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly wo Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€455,00 Add to cart -
Collagen I [COL1]
Description The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. This clone reacts collagen I. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine), Cat, Dog
1 ml more info 14 days
€401,70 Add to cart -
Collagen I [COL1]
Description The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. This clone reacts collagen I. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine), Cat, Dog
7 ml more info 14 days
€187,20 Add to cart
