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Article number: RC0329

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CD64/IGFR1 Polyclonal

Description	This antibody recognizes CD64 also known as FcRI. CD64 is a high affinity activatory receptor for IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. The interaction between Fc receptors and antibodies play important roles in both the innate and adaptive immune responses. CD64 through binding of the Fc segment of IgG, mediates phagocytosis and plays a role in antibody-dependent cellular cytotoxicity and clearance of immune complexes. In addition, CD64 also functions as an antigen capture for presentation to T-cells and also mediates the release of cytokines and reactive oxygen intermediates including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) alpha. It is constitutively expressed on monocytes and macrophages, germinal centre dendritic cells and early myeloid lineage cells, but not lymphocytes. Expression on monocytes can be strongly upregulated by treatment with interferon (IFN) gamma or G-CSF, and can be induced on neutrophils and eosinophils by IFN gam
Host	Rabbit
Application	ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: RC0329RTU7

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Description	This antibody recognizes CD64 also known as FcRI. CD64 is a high affinity activatory receptor for IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. The interaction between Fc receptors and antibodies play important roles in both the innate and adaptive immune responses. CD64 through binding of the Fc segment of IgG, mediates phagocytosis and plays a role in antibody-dependent cellular cytotoxicity and clearance of immune complexes. In addition, CD64 also functions as an antigen capture for presentation to T-cells and also mediates the release of cytokines and reactive oxygen intermediates including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) alpha. It is constitutively expressed on monocytes and macrophages, germinal centre dendritic cells and early myeloid lineage cells, but not lymphocytes. Expression on monocytes can be strongly upregulated by treatment with interferon (IFN) gamma or G-CSF, and can be induced on neutrophils and eosinophils by IFN gam
Host	Rabbit
Application	ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: MC0347

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Description	TDP43 or TAR DNA-binding protein 43 belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. It is also is involved in transcriptional regulation and exon splicing. While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. (Shipping Cost: €200.00)
Host	Mouse
Application	Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: MC0103

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Description	It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TYRP-1). It is involved in melanin synthesis. TYRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TYRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TYRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. (Shipping Cost: €200.00)
Host	Mouse
Application	Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
Reactivity	Human, Mouse

Article number: MF021M

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Description	MedaFluo™ 488 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse

Article number: MF021S

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Description	MedaFluo™ 488 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse

Article number: MF022M

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Description	MedaFluo™ 550 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse

Article number: MF022S

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Description	MedaFluo™ 550 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse

Article number: MF023M

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Description	MedaFluo™ 594 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse

Article number: MF023S

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Description	MedaFluo™ 594 Rat on Mouse Immunofluorescence Detection Kit (Shipping Cost: €200.00)
Host	Rat
Reactivity	Mouse