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Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog 
1 ml more info 
14 days 
€374,40 Add to cart -
Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog
7 ml more info 14 days
€187,20 Add to cart -
CD69 Polyclonal
Description CD69 is also known as activation-induced molecule (AIM), early activation antigen (EA-1), very early activation antigen (VEA), C-type lectin domain family 2 member C (CLEC2C), MLR-3, GP32/28 and Leu-23. CD69 is a transmembrane type II homodimer receptor. CD69 is comprised of disulfide-linked, differentially glycosylated core protein subunits that are approximately 28 and 34 kDa in size. Each subunit contains a C-type lectin domain. CD69 is expressed on activated T, B, and natural killer (NK) lymphocytes, thymocytes, neutrophils, eosinophils and platelets. In normal peripheral blood, a small and variable percentage of lymphocytes typically express detectable membrane CD69 antigen. Upon activation, CD69 antigen expression increases on lymphocytes. Peak CD69 expression generally occurs within 18 hours of activation, preceding the appearance of HLA-DR, IL-2Rα (CD25) and transferrin receptor (CD71). CD69 is highly expressed on the bright CD3+ subset of thymocytes. FN50 monoclonal antibody l Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog 
1 ml more info 14 days
€401,70 Add to cart -
CD69 Polyclonal
Description CD69 is also known as activation-induced molecule (AIM), early activation antigen (EA-1), very early activation antigen (VEA), C-type lectin domain family 2 member C (CLEC2C), MLR-3, GP32/28 and Leu-23. CD69 is a transmembrane type II homodimer receptor. CD69 is comprised of disulfide-linked, differentially glycosylated core protein subunits that are approximately 28 and 34 kDa in size. Each subunit contains a C-type lectin domain. CD69 is expressed on activated T, B, and natural killer (NK) lymphocytes, thymocytes, neutrophils, eosinophils and platelets. In normal peripheral blood, a small and variable percentage of lymphocytes typically express detectable membrane CD69 antigen. Upon activation, CD69 antigen expression increases on lymphocytes. Peak CD69 expression generally occurs within 18 hours of activation, preceding the appearance of HLA-DR, IL-2Rα (CD25) and transferrin receptor (CD71). CD69 is highly expressed on the bright CD3+ subset of thymocytes. FN50 monoclonal antibody l Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€174,20 Add to cart -
GLB1/Beta-galactosidase Polyclonal
Description The human b-galactosidase gene, known as the LacZ gene, are widespread in animals, microorganisms and plants. Beta galactosidase antibody plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. (Shipping Cost: €200.00) Host Rabbit Application Peptide ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
1 ml more info 14 days
€388,70 Add to cart -
GLB1/Beta-galactosidase Polyclonal
Description The human b-galactosidase gene, known as the LacZ gene, are widespread in animals, microorganisms and plants. Beta galactosidase antibody plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. (Shipping Cost: €200.00) Host Rabbit Application Peptide ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€201,50 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
1 ml more info 14 days
€361,40 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€187,20 Add to cart -
Melanoma PNL2 [PNL2]
Description PNL2 antibody labels intraepidermal nevi while the dermal component of compound nevi is largely non-reactive with anti-PNL2. PNL2, MART-1/Melan-A and HMB45 antibodies stain most clear cell sarcoma cells and a few cells in angiomyolipomas and lymphangioleiomyomatosis. Non-melanocytic lesions found to be positive with this marker include PEComas and melanotic schwannoma. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, Tyrosinase, and MiTF. The differential diagnosis between benign nevi and malignant melanoma is sometimes difficult, and malignant melanoma may mimic other neoplasms, such as undifferentiated carcinoma, sarcoma or large cell lymphoma. PNL2 is more sensitive for metastatic melanoma (87%) than HMB45 (76%) and MART-1 (82%). A panel of PNL2, S-100 and HMB45 is a highly sensitive and specific marker for mucosal melanoma Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Dog
1 ml more info 14 days
€361,40 Add to cart -
Melanoma PNL2 [PNL2]
Description PNL2 antibody labels intraepidermal nevi while the dermal component of compound nevi is largely non-reactive with anti-PNL2. PNL2, MART-1/Melan-A and HMB45 antibodies stain most clear cell sarcoma cells and a few cells in angiomyolipomas and lymphangioleiomyomatosis. Non-melanocytic lesions found to be positive with this marker include PEComas and melanotic schwannoma. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, Tyrosinase, and MiTF. The differential diagnosis between benign nevi and malignant melanoma is sometimes difficult, and malignant melanoma may mimic other neoplasms, such as undifferentiated carcinoma, sarcoma or large cell lymphoma. PNL2 is more sensitive for metastatic melanoma (87%) than HMB45 (76%) and MART-1 (82%). A panel of PNL2, S-100 and HMB45 is a highly sensitive and specific marker for mucosal melanoma Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Dog
7 ml more info 14 days
€187,20 Add to cart
