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KRAS Polyclonal
Description This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€201,50 Add to cart -
LI/Leukemia Inhibitory Factor Polyclonal
Description LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Lysozyme/Muramidase [EPR2994(2)]
Description Lysozyme is a ubiquitous enzyme defined as muraminidase catalyzing the hydrolysis of the beta glycosidic bond in bacterial peptidoglycan, a major component of the bacterial cell wall. Lysozyme in tissues and body fluids is associated with the monocyte-macrophage system and enhances the activity of immunoagents. Lysozyme C catalyzes the hydrolysis of certain mucopolysaccharides of bacterial cell walls. Specifically, it catalyzes the hydrolysis of the bacterial cell wall beta glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine. It is found in the spleen, lung, kidney, white blood cells, plasma, saliva, milk, and tears. Defects in Lysozyme C are a cause of amyloidosis type 8 (AMYL8), also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. Lysozyme immunoreactivity has been found in myeloid cells, histiocytes, granulocytes, macrophages, and monocytes. It is a good marker for macrophages that are activated in phagocytosis. Lysozyme has been usef Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse 
1 ml more info 14 days
€464,10 Add to cart -
Lysozyme/Muramidase [EPR2994(2)]
Description Lysozyme is a ubiquitous enzyme defined as muraminidase catalyzing the hydrolysis of the beta glycosidic bond in bacterial peptidoglycan, a major component of the bacterial cell wall. Lysozyme in tissues and body fluids is associated with the monocyte-macrophage system and enhances the activity of immunoagents. Lysozyme C catalyzes the hydrolysis of certain mucopolysaccharides of bacterial cell walls. Specifically, it catalyzes the hydrolysis of the bacterial cell wall beta glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine. It is found in the spleen, lung, kidney, white blood cells, plasma, saliva, milk, and tears. Defects in Lysozyme C are a cause of amyloidosis type 8 (AMYL8), also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. Lysozyme immunoreactivity has been found in myeloid cells, histiocytes, granulocytes, macrophages, and monocytes. It is a good marker for macrophages that are activated in phagocytosis. Lysozyme has been usef Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€254,80 Add to cart -
MAP3K3/MEKK3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) [5C1]
Description MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€546,00 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
1 ml more info 14 days
€361,40 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€187,20 Add to cart -
MCM2 [MD32R]
Description Minichromosome maintenance protein 2 (MCM2), also known as DNA replication licensing factor MCM2, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM2 acts as a factor to license DNA for one and only one round of replication per cell cycle. In the cell cycle, levels of the MCM family gradually increase in a variable manner from G0 into the G1/S phase. In the G0 stage, the amounts of MCM2 and MCM5 proteins are much lower than that of MCM7 and MCM3 proteins, so some of them participate in cell cycle regulation. MCM2 is localized in the nucleus throughout interphase. It is required for entry into the S phase and cell division. Anti-MCM2 labels proliferating cells in normal and tumor tissue. MCM2 has been Host Rabbit Application Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Monkey
1 ml more info 14 days
€442,00 Add to cart -
MCM2 [MD32R]
Description Minichromosome maintenance protein 2 (MCM2), also known as DNA replication licensing factor MCM2, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM2 acts as a factor to license DNA for one and only one round of replication per cell cycle. In the cell cycle, levels of the MCM family gradually increase in a variable manner from G0 into the G1/S phase. In the G0 stage, the amounts of MCM2 and MCM5 proteins are much lower than that of MCM7 and MCM3 proteins, so some of them participate in cell cycle regulation. MCM2 is localized in the nucleus throughout interphase. It is required for entry into the S phase and cell division. Anti-MCM2 labels proliferating cells in normal and tumor tissue. MCM2 has been Host Rabbit Application Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Monkey
7 ml more info 14 days
€254,80 Add to cart -
MDM2 [SMP14]
Description p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNAdamaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wt p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. MDM2 is useful in differentiating liposarcoma from other types of sarcomas. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart
