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SPINK5/LEKTI [E9]
Description Serine peptidase inhibitor Kazal type 5 (SPINK5), also known Lympho-epithelial Kazal-type inhibitor (LEKTI) which is highly expressed in the thymus and stratum corneum, protects mucous epithelia against microbial attack and inflammation. SPINK5 is found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. SPINK5 is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5 are the cause of Netherton syndrome (NETH), a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
Tartarate Resistant Acid Phosphatase (TRAcP/TRAP5) [ACP5/1070]
Description Tartrate resistant acid phosphatase (TRAcP) is a basic, iron-binding protein with high activity towards phosphoproteins, ATP and 4 nitrophenyl phosphate. Expression of TRAcP is reported to be increased in the spleen and monocytes of individuals with Gaucher’s disease, splenocytes and circulating white cells of individuals with hairy cell leukemia, spleens of individuals with Hodgkin disease, and the sera of individuals undergoing active bone turnover. Elevated levels are also reported to be associated with various B-cell and T-cell leukemias and lymphomas, placental decidual cells, syncytiotrophoblasts, and some macrophages distributed throughout maternal and embryonic tissues. The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specificity. Worthy also of mention in this regard are anti-annexin A1 and Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse,Rat
1 ml more info 14 days
€361,40 Add to cart -
Tartarate Resistant Acid Phosphatase (TRAcP/TRAP5) [ACP5/1070]
Description Tartrate resistant acid phosphatase (TRAcP) is a basic, iron-binding protein with high activity towards phosphoproteins, ATP and 4 nitrophenyl phosphate. Expression of TRAcP is reported to be increased in the spleen and monocytes of individuals with Gaucher’s disease, splenocytes and circulating white cells of individuals with hairy cell leukemia, spleens of individuals with Hodgkin disease, and the sera of individuals undergoing active bone turnover. Elevated levels are also reported to be associated with various B-cell and T-cell leukemias and lymphomas, placental decidual cells, syncytiotrophoblasts, and some macrophages distributed throughout maternal and embryonic tissues. The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specificity. Worthy also of mention in this regard are anti-annexin A1 and Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse,Rat
7 ml more info 14 days
€187,20 Add to cart -
Thyroglobulin [2H11+6E1]
Description Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3, and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis. Thyroglobulin is found in normal thyroid and differentiated thyroid carcinoma cells but not undifferentiated thyroid. Thyroglobulin is a useful marker for identification of tumors with thyroid origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Thyroglobulin [2H11+6E1]
Description Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3, and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis. Thyroglobulin is found in normal thyroid and differentiated thyroid carcinoma cells but not undifferentiated thyroid. Thyroglobulin is a useful marker for identification of tumors with thyroid origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Transgelin (SM22-alpha) [SPM606]
Description This antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine,Pig (Porcine), Rabbit, Mouse
1 ml more info 14 days
€361,40 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Tumor necrosis factor/TNF alpha [TNFA/1172]
Description Tumor necrosis factor alpha (TNF-alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNFalpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS-PAGE under non-reducing conditions. TNF-alpha is closely related to the 25kDa protein tumor necrosis factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF-alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNFalpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of i Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat, Rabbit, Cat, Dog
1 ml more info 14 days
€361,40 Add to cart -
Tumor necrosis factor/TNF alpha [TNFA/1172]
Description Tumor necrosis factor alpha (TNF-alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNFalpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS-PAGE under non-reducing conditions. TNF-alpha is closely related to the 25kDa protein tumor necrosis factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF-alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNFalpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of i Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat, Rabbit, Cat, Dog
7 ml more info 14 days
€187,20 Add to cart
