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  • Article number: MC0565
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    p57/Kip2 [KP10]

    Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human, Mouse
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
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  • Article number: MC0565RTU7
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    p57/Kip2 [KP10]

    Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human, Mouse
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €187,20 
    Add to cart
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