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p57/Kip2 [KP10]
Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse 
1 ml more info 
14 days 
€361,40 Add to cart -
p57/Kip2 [KP10]
Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart
