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CITED1/MSG1 [5H6]
Description CITED1 belongs to CITED family and only in melanocytes and testis. It is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation. It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state. Wilms’ tumors are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys. CITED1 expression has been shown to persist in blastemal cell populations of human WT. In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells. It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€494,00 Add to cart -
Claudin 4 [A12]
Description The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23. Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Claudin 4 [A12]
Description The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-4 is not expressed in rat liver, whereas in pancreas, claudin-4 is localized to junctions of the duct epithelia and junctions of acinar cells. In the rat gut, claudin-4 displays highly restricted expression to colonic surface cells. The human claudin-4 gene maps to chromosome 7q11.23. Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€464,10 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€254,80 Add to cart -
Claudin 8 [EPR12680(2)]
Description Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast. Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly wo Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€520,00 Add to cart -
Claudin 8 [EPR12680(2)]
Description Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast. Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly wo Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€455,00 Add to cart -
CMV [8B1.2/1G5.2/2D4.2]
Description Cytomegalovirus (CMV) is a member of the family Herpesviridae, which includes Epstein-Barr virus, herpes simplex virus types 1 and 2, varicella-zoster virus, and human herpesvirus 6. CMV is the most common identified cause of congenital infection. Found in several body fluids including saliva, urine, breast milk, cervical secretions, blood, and semen, CMV can be transmitted in a variety of ways, such as blood transfusion and organ transplantation. The typical morphology of infected tissue includes enlarged cells (often to a diameter of 40 mm) with intranuclear, and on occasion, cytoplasmic inclusions. The intranuclear inclusions may measure 17mm in diameter and are usually set off from the nuclear membrane by a clear halo. Not all CMV-infected cells demonstrate the “classic” cytopathic effects associated with antigen of 68 kD found in the nucleus of infected cells. It also immunoprecipitates antigens of 38, 43, 46, and 49 kD. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CMV [8B1.2/1G5.2/2D4.2]
Description Cytomegalovirus (CMV) is a member of the family Herpesviridae, which includes Epstein-Barr virus, herpes simplex virus types 1 and 2, varicella-zoster virus, and human herpesvirus 6. CMV is the most common identified cause of congenital infection. Found in several body fluids including saliva, urine, breast milk, cervical secretions, blood, and semen, CMV can be transmitted in a variety of ways, such as blood transfusion and organ transplantation. The typical morphology of infected tissue includes enlarged cells (often to a diameter of 40 mm) with intranuclear, and on occasion, cytoplasmic inclusions. The intranuclear inclusions may measure 17mm in diameter and are usually set off from the nuclear membrane by a clear halo. Not all CMV-infected cells demonstrate the “classic” cytopathic effects associated with antigen of 68 kD found in the nucleus of infected cells. It also immunoprecipitates antigens of 38, 43, 46, and 49 kD. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
c-Myb Phospho Ser11 [SZ04-81]
Description The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells. Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth. c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€546,00 Add to cart
