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Plasma Cells [LIV3G11 (7B18)]
Description Plasma cells, which are large lymphocytes derived from an antigen-specific B-cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B-cells upon stimulation by CD4+ lymphocytes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this antibody is not suitable for staining frozen tissues. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker) [3D3]
Description Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Rabbit, Rat
1 ml more info 14 days
€361,40 Add to cart -
Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker) [3D3]
Description Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Rabbit, Rat
7 ml more info 14 days
€187,20 Add to cart -
Podoplanin [D2-40]
Description D2-40, also known as Podoplanin and Lymphatic Endothelial Cell Marker. It is expressed in lymphatic endothelium, and was found in lymphangiomas, Kaposi sarcomas, a subset of angiosarcomas with lymphatic differentiation, epithelioid mesotheliomas, hemangioblastomas, seminomas. D2-40 is a useful marker in identification of lymphatic invasion of primary tumors. D2-40 has also known to be a specific marker for cells of mesothelial origin e.g. mesothelioma. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
Podoplanin [D2-40]
Description D2-40, also known as Podoplanin and Lymphatic Endothelial Cell Marker. It is expressed in lymphatic endothelium, and was found in lymphangiomas, Kaposi sarcomas, a subset of angiosarcomas with lymphatic differentiation, epithelioid mesotheliomas, hemangioblastomas, seminomas. D2-40 is a useful marker in identification of lymphatic invasion of primary tumors. D2-40 has also known to be a specific marker for cells of mesothelial origin e.g. mesothelioma. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
PolyQ/Polyglutamine-Expansion Diseases Marker [5TF1-1C2]
Description Polyglutamine tract are portions of a protein consisting of a sequence of several glutamine unit. Several inheritable neurodegenerative disorders, so-called polyglutamine diseases, occur if a mutation causes a polyglutamine tract in a specific gene to become too long. Important examples of polyglutamine diseases include Huntington's disease, dentatorubralpallidoluysian atrophy (DRPLA), spinobulbar muscular atrophy (SBMA) and types of spinocerebellar ataxia (SCA). In these diseases, the pathogenic alleles usually contain 39 or more consecutive glutamine repeats. Higher repeat numbers lead to lower ages of onset. Patients with 40-60 glutamine repeats normally develop disease as adults, whereas patients with more than 60 repeats develop a juvenile onset disease. Each polyglutamine expansion disorder displays characteristic pathology, with neuronal loss evident in specific regions of the brain. It is believed that cells cannot properly dispose of proteins with overlong polyglutamine tracts Host Mouse Application ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€624,00 Add to cart -
PR [PR484]
Description The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family. PR exists in humans as two isoforms. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary, but is also found in other tissues such as prostate stromal cells, anterior pituitary gland, and endocrine cells of the Langerhans' islets. The antibody reacts with both isoforms of human PR. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€442,00 Add to cart -
PR [PR484]
Description The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family. PR exists in humans as two isoforms. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary, but is also found in other tissues such as prostate stromal cells, anterior pituitary gland, and endocrine cells of the Langerhans' islets. The antibody reacts with both isoforms of human PR. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€338,00 Add to cart -
ProExC (TOP2A&MCM2) [TOP2A/1362&MCM2/3678]
Description Minichromosome maintenance and topoisomerase II alpha proteins play an important role in the regulation of eukaryotic DNA replication, and are overexpressed in a number of dysplastic and malignant tissues. ProExC antibody is a novel biomarker cocktail containing antibodies against topoisomerase II alpha and minichromosome maintenance 2 proteins. When up regulated, ProExC serves as a marker of aberrant S-phase induction in proliferating cells. ProExC expression can be applied an independent risk factor for low grade squamous intraepithelial lesion (LSIL) progression. ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia, distinguishing adenocarcinoma in situ from reactive benign endocervix. ProExC may be used in conjunction with morphologic and human papillomavirus (HPV) evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€598,00 Add to cart -
ProExC (TOP2A&MCM2) [TOP2A/1362&MCM2/3678]
Description Minichromosome maintenance and topoisomerase II alpha proteins play an important role in the regulation of eukaryotic DNA replication, and are overexpressed in a number of dysplastic and malignant tissues. ProExC antibody is a novel biomarker cocktail containing antibodies against topoisomerase II alpha and minichromosome maintenance 2 proteins. When up regulated, ProExC serves as a marker of aberrant S-phase induction in proliferating cells. ProExC expression can be applied an independent risk factor for low grade squamous intraepithelial lesion (LSIL) progression. ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia, distinguishing adenocarcinoma in situ from reactive benign endocervix. ProExC may be used in conjunction with morphologic and human papillomavirus (HPV) evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€338,00 Add to cart
