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MALT1 [MLT1/410]
Description Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
MALT1 [MLT1/410]
Description Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Mammaglobin [304-1A5]
Description The Mammaglobin gene encodes a 10-kDa glycoprotein that is homolog to human Clara cell 10-kDa protein (CC10)/uteroglobin. SCGB2A2. Expression of the mammaglobin gene is highly restricted to the adult mammary gland. Antibody to Mammaglobin labels normal breast epithelial cells and breast tumor cells. It is a useful marker for identification of primary and metastatic breast cancer. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Mammaglobin [304-1A5]
Description The Mammaglobin gene encodes a 10-kDa glycoprotein that is homolog to human Clara cell 10-kDa protein (CC10)/uteroglobin. SCGB2A2. Expression of the mammaglobin gene is highly restricted to the adult mammary gland. Antibody to Mammaglobin labels normal breast epithelial cells and breast tumor cells. It is a useful marker for identification of primary and metastatic breast cancer. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) [2F6]
Description Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFĪŗB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
1 ml more info 14 days
€361,40 Add to cart -
MART-1/Melan A [A103]
Description MART-1, also known as Melan-A, is a melanocyte lineage-specific protein (MART-1; melanoma antigen recognized by T cells 1) recognized by the T lymphocytes of patients with established malignancy. MART-1 labels both normal melanocyte and diseased cell with melanocyte differentiation. It is useful for diagnosis of tumors with melanocyte differentiation, especially metastatic melanoma. Identification of MART-1 also opens possibilities for the development of immunotherapies for patients with melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Dog
7 ml more info 14 days
€187,20 Add to cart -
MCM2 [MCM2/3678]
Description Minichromosome maintenance protein 2 (MCM2), also known as DNA replication licensing factor MCM2, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM2 acts as a factor to license DNA for one and only one round of replication per cell cycle. In the cell cycle, levels of the MCM family gradually increase in a variable manner from G0 into the G1/S phase. In the G0 stage, the amounts of MCM2 and MCM5 proteins are much lower than that of MCM7 and MCM3 proteins, so some of them participate in cell cycle regulation. MCM2 is localized in the nucleus throughout interphase. It is required for entry into the S phase and cell division. Anti-MCM2 labels proliferating cells in normal and tumor tissue. MCM2 has been Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
MCM2 [MCM2/3678]
Description Minichromosome maintenance protein 2 (MCM2), also known as DNA replication licensing factor MCM2, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. MCM2 acts as a factor to license DNA for one and only one round of replication per cell cycle. In the cell cycle, levels of the MCM family gradually increase in a variable manner from G0 into the G1/S phase. In the G0 stage, the amounts of MCM2 and MCM5 proteins are much lower than that of MCM7 and MCM3 proteins, so some of them participate in cell cycle regulation. MCM2 is localized in the nucleus throughout interphase. It is required for entry into the S phase and cell division. Anti-MCM2 labels proliferating cells in normal and tumor tissue. MCM2 has been Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MDM2 [SMP14]
Description p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNAdamaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wt p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. MDM2 is useful in differentiating liposarcoma from other types of sarcomas. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart
