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Cyclin B3 (CCNB3) Polyconal
Description Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. Cyclin B3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Horse,Pig (Porcine), Sheep 
7 ml more info 
14 days 
€174,20 Add to cart -
Cyclin B3 (CCNB3) Polyconal+B200
Description Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. Cyclin B3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Horse,Pig (Porcine), Sheep
1 ml more info 14 days
€494,00 Add to cart -
Cytochrome C [7H8.2C12]
Description Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC)/IF Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Horse, Dog (Canine), Pigeon, Frog, Drosophila 
1 ml more info 14 days
€361,40 Add to cart -
Cytochrome C [7H8.2C12]
Description Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC)/IF Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Horse, Dog (Canine), Pigeon, Frog, Drosophila
7 ml more info 14 days
€187,20 Add to cart -
OTK4/FKBP1B/FKBP12.6 [H8]
Description Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBPtype PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, equine, Dog (Canine), Bovine, Pig
1 ml more info 14 days
€361,40 Add to cart -
TAG-72/CA72.4 [B72.3]
Description Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and most human adenocarcinomas, including colorectal, gastric, pancreatic, mammary, and ovarian. Antibody B72.3 recognizes a carbohydrate epitope identified as sialylated Tn antigen. This antigen is expressed by invasive ductal breast carcinomas, colon, pancreatic, gastric, esophageal, lung, ovarian and endometrial adenocarcinomas. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Dog (Canine), Hamster, Rat
1 ml more info 14 days
€361,40 Add to cart -
TAG-72/CA72.4 [B72.3]
Description Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and most human adenocarcinomas, including colorectal, gastric, pancreatic, mammary, and ovarian. Antibody B72.3 recognizes a carbohydrate epitope identified as sialylated Tn antigen. This antigen is expressed by invasive ductal breast carcinomas, colon, pancreatic, gastric, esophageal, lung, ovarian and endometrial adenocarcinomas. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Dog (Canine), Hamster, Rat
7 ml more info 14 days
€187,20 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian
1 ml more info 14 days
€374,40 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian
7 ml more info 14 days
€174,20 Add to cart
