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TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey 
1 ml more info 
14 days 
€507,00 Add to cart -
TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
Monoclonal antibody to human IFN-gamma (clone MD-1)
Description The monoclonal antibody to human IFN-γ (clone MD-1) was first described in 1985. It has shown to neutralize the antiviral activity of both natural and recombinant human IFN-γ and in a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-1 antibody has been descripted as useful in a sandwich ELISA and in ELISPOT assays. Further, the antibody has proven to cross react with chimpanzee and rhesus macaque IFN-γ and can be used for immunohistochemical staining of frozen tissues. The MD-1 antibody has been reported for use in intracellular flow cytometric analysis and in Luminex systems. Other available formats: biotin labeled (cat. no. CT218) and FITC labeled (cat. no. CT220). (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Chimpanzee,Rhesus Macaque
0 0.5 mg more info 8 days
€325,00 Add to cart -
Monoclonal antibody to human IFN-gamma (clone MD-2)
Description The monoclonal antibody to human IFN-γ (clone MD-2) was first described in 1985. It has shown to binds with high affinity to both natural and recombinant human IFN-γ but does not neutralize the antiviral bioactivity of IFN-γ in vitro. In a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-2 antibody has been descripted as useful in a sandwich ELISA. Further, the antibody has proven to cross react with rhesus macaque, cynomolgus monkey and marmoset IFN-γ and can be used for immunohistochemical staining of frozen tissues. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Immunohistochemistry on frozen sections (IHC-Fs),Western Blot (WB) Reactivity Rhesus Macaque,Cynomolgus Monkey,Marmoset
0 mg more info 8 days
€300,00 Add to cart -
Monoclonal antibody to monkey IFN-gamma (clone MD-1)
Description The neutralizing monoclonal antibody to monkey IFN-γ (clone MD-1) was first described in 1985. The MD-1 antibody can be used in a sandwich ELISA and in ELISPOT assays. Further, the antibody has been descripted in immunohistochemical staining of frozen tissues of marmosets and in intracellular flow cytometric analysis. The MD-1 antibody has been reported to cross react with rhesus macaque, pig-tailed macaque, cynomogus monkey, baboon and African green monkey IFN-γ and can be used in Luminex systems. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Rhesus Macaque,Cynomolgus Monkey,Pig-tailed Macaque,Japanese Macaque,Crested Black Macaque,Barbary Macaque,Lion-tailed Macaque,Baboon,Mandrill,African Green Monkey (Chlorocebus),Black Mangabey
0 mg more info 8 days
€325,00 Add to cart -
Monoclonal antibody to rat IFN-gamma (clone DB-1)
Description The mouse anti-rat IFN-γ monoclonal antibody (clone DB-1) was first described by Van der Meide P.H. et al. in 1989. The rat IFN-γ antibody is of the IgG1 subtype and neutralizes both natural and recombinant rat IFN-γ and mouse IFN-γ in vitro and in vivo. In Western blot analysis the DB-1 antibody reacts with the 14 kDa and 18 kDa polypeptides present in rat IFN-γ with moderate activity. Clone DB-1 has shown not to bind with rat IFN-α and IFN-β nor human IFNs. Further, biotinyated DB-1 antibody (cat. no. CT035) is highly effective as detector antibody in both sandwich ELISA and ELISPOT assays using DB-12 (cat no. CT052) as coating antibody. Also the reverse combination in which the DB-1 antibody functions as coating antibody and biotinylated DB-12 antibody (cat. no. CT033) or biotinylated polyclonal antibody to rat IFN-γ as detector antibody can be used in an ELISA and ELISPOT systems. The DB-1 antibody is also applicable in immunohistochemistry on frozen tissues and intracellular stain Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB)
0 mg more info 8 days
€325,00 Add to cart -
Monoclonal antibody to rat IFN-gamma (clone DB-12)
Description The mouse anti-rat IFN-γ monoclonal antibody (clone DB-12) was first described by Van der Meide P.H. et al. in 1989. The rat IFN-γ antibody is of the IgG1 subtype and possesses very low neutralizing activity. In Western blot analysis the DB-12 antibody reacts with the 14 kDa and 18 kDa polypeptides present in rat IFN-γ with moderate activity and it has shown not to bind with either mouse IFN-γ nor human IFN-γ. Further, the DB-12 antibody is highly effective as coating antibody in both sandwich ELISA and ELISPOT assays using biotinylated DB-1 antibody (cat no. CT035) for detection. Also the reverse combination in which the DB-1 antibody (cat. no. CT032) functions as coating antibody and biotinylated DB-12 antibody (cat. no. CT033) as detector can be used in an ELISA system. The DB-12 antibody is also applicable in immunohistochemistry on frozen tissues and intracellular staining. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Immunohistochemistry on frozen sections (IHC-Fs),Western Blot (WB)
0 mg more info 8 days
€405,00 Add to cart
