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NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey 
1 ml more info 
14 days 
€494,00 Add to cart -
NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
Neogenin 1/NEO1 [MD160]
Description Neogenin (NEO1) is a type I transmembrane protein that is crucial for axonal guidance and neuronal migration. It is also involved in regulating differentiation programs in many embryonic and adult tissues. It is a member of the immunoglobulin (Ig) superfamily and is closely related to deleted in colorectal cancer (DCC). NEO and DCC, together with the UNC5 family of type I transmembrane proteins, are receptors for the netrin/UNC6 family of laminin-related bifunctional guidance molecules that both attract some axons and repel others. In mouse, at least five netrins (netrin‑1, ‑3, -4, G1, and G2) have been identified. Mouse netrin-1 and netrin-3 have been shown to be ligands for mouse NEO. Neogenin protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coi Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€535,60 Add to cart -
Netrin 1 Polyclonal
Description Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
1 ml more info 14 days
€520,00 Add to cart -
NeuN [A60]
Description NeuN antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuro. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists a Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Avian, Chicken, Ferret, Human, Mouse,Pig (Porcine), Rat, Salamander
1 ml more info 14 days
€361,40 Add to cart -
NeuN [A60]
Description NeuN antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuro. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists a Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Avian, Chicken, Ferret, Human, Mouse,Pig (Porcine), Rat, Salamander
7 ml more info 14 days
€187,20 Add to cart -
Neurofilament [2F11]
Description Neuofilaments (NF) are members of the intermediate filament protein family. These neuron-specific filaments are the major constituents of the axonal cytoskeleton . NFs are composed of three major proteins: NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa). The NF-L and NF-M mRNAs are detected early in the embryonal brain, with a progressive increase in their levels during development, while the NF-H mRNA is barely detectable at embryonal stages but accumulates later in the postnatal brain. This antibody labels neurons of the central and peripheral nervous system, and is a useful for the identification of tumors with neuronal differentiation (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Neurofilament [2F11]
Description Neuofilaments (NF) are members of the intermediate filament protein family. These neuron-specific filaments are the major constituents of the axonal cytoskeleton . NFs are composed of three major proteins: NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa). The NF-L and NF-M mRNAs are detected early in the embryonal brain, with a progressive increase in their levels during development, while the NF-H mRNA is barely detectable at embryonal stages but accumulates later in the postnatal brain. This antibody labels neurons of the central and peripheral nervous system, and is a useful for the identification of tumors with neuronal differentiation (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog
1 ml more info 14 days
€442,00 Add to cart -
NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog
7 ml more info 14 days
€254,80 Add to cart
