CD133, also known as prominin or AC133, is a marker frequently found on multipotent progenitor cells, including immature hematopoietic stem and progenitor cells. The protein has been extensively used as a stem cell marker for normal and cancerous tissues. May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. (Shipping Cost: €200.00)
CD133, also known as prominin or AC133, is a marker frequently found on multipotent progenitor cells, including immature hematopoietic stem and progenitor cells. The protein has been extensively used as a stem cell marker for normal and cancerous tissues. May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. (Shipping Cost: €200.00)
