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Caveolin 1 (CAV1) [6C2B2]
Description Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, α and ß, due to alternate splicing of the mRNA. Caveolin-1 forms large lipid-binding ho Host Mouse Application Bioimg , Immunohistochemistry (IHC) , Immunoprecipitation (IP) , Western Blot (WB) Reactivity Human, Mouse, Rat, Dog (Canine), Rabbit 
1 ml more info 
14 days 
€429,00 Add to cart -
Caveolin 1 (CAV1) [6C2B2]
Description Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, α and ß, due to alternate splicing of the mRNA. Caveolin-1 forms large lipid-binding ho Host Mouse Application Bioimg , Immunohistochemistry (IHC) , Immunoprecipitation (IP) , Western Blot (WB) Reactivity Human, Mouse, Rat, Dog (Canine), Rabbit
7 ml more info 14 days
€254,80 Add to cart -
OTK4/FKBP1B/FKBP12.6 [H8]
Description Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBPtype PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, equine, Dog (Canine), Bovine, Pig
1 ml more info 14 days
€361,40 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian 
1 ml more info 14 days
€374,40 Add to cart -
Tuberin/TSC2 Polyclonal
Description Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Equine, Dog (Canine),Pig (Porcine), Avian
7 ml more info 14 days
€174,20 Add to cart -
Tubulin Alpha [TUBA/3038]
Description Tubulin is a heterodimer consisting of alpha and beta-tubulin subunits. It is nearly ubiquitous among eukaryotic cells. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha-beta tubulin heterodimer is the basic building block of microtubules. This intracellular cylindrical filamentous structure is present in almost eukaryotic cells. Microtubules serve as structural supports and lines of transport within the cell, as well as serving a key role in mitosis. (Shipping Cost: €200.00) Host Mouse Application EM, FCM, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Avian, Bovine, Dog (Canine), Chicken, Drosophila, Fungi, Guinea Pig, Hamster, Mouse,Pig (Porcine), Primates, Rabbit, Rat, Xenopus
1 ml more info 14 days
€361,40 Add to cart -
Tubulin Alpha [TUBA/3038]
Description Tubulin is a heterodimer consisting of alpha and beta-tubulin subunits. It is nearly ubiquitous among eukaryotic cells. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha-beta tubulin heterodimer is the basic building block of microtubules. This intracellular cylindrical filamentous structure is present in almost eukaryotic cells. Microtubules serve as structural supports and lines of transport within the cell, as well as serving a key role in mitosis. (Shipping Cost: €200.00) Host Mouse Application EM, FCM, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Avian, Bovine, Dog (Canine), Chicken, Drosophila, Fungi, Guinea Pig, Hamster, Mouse,Pig (Porcine), Primates, Rabbit, Rat, Xenopus
7 ml more info 14 days
€187,20 Add to cart
