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PCNA [PC10]
Description Proliferating cell nuclear antigen (PCNA) is a DNA polymerase accessory factor that is required for DNA replication during S phase of the cell cycle and for resynthesis during nucleotide excision repair of damaged DNA. The PCNA antibody detects proliferating cells in both normal and tumor cells. Anti-PCNA labeling index has been shown to be associated with tumor prognosis. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat, Chicken, Zebrafish, Drosophila melanogaster, Yeast -
PCNA [PC10]
Description Proliferating cell nuclear antigen (PCNA) is a DNA polymerase accessory factor that is required for DNA replication during S phase of the cell cycle and for resynthesis during nucleotide excision repair of damaged DNA. The PCNA antibody detects proliferating cells in both normal and tumor cells. Anti-PCNA labeling index has been shown to be associated with tumor prognosis. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat, Chicken, Zebrafish, Drosophila melanogaster, Yeast -
PD-1/PDCD1/CD279 [PDCD1/922]
Description Programmed death-1 (PD1) is a member of the CD28 family of receptors that includes CD28, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), inducible costimulator (ICOS), and B- and T-lymphocyte attenuator. These receptors play a role in the cellular immune response. PD1 is a new marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and bcl-6, PD1 is expressed by few B cells, so it may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. It also seems to stain a greater percentage of CD3-positive neoplastic cells in angioimmunoblastic lymphoma than either CD10 or bcl-6. In addition, PD1 expression provides new evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T cells. PD1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T cells may undergo neoplastic transformation and result in Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
PD-1/PDCD1/CD279 [PDCD1/922]
Description Programmed death-1 (PD1) is a member of the CD28 family of receptors that includes CD28, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), inducible costimulator (ICOS), and B- and T-lymphocyte attenuator. These receptors play a role in the cellular immune response. PD1 is a new marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and bcl-6, PD1 is expressed by few B cells, so it may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. It also seems to stain a greater percentage of CD3-positive neoplastic cells in angioimmunoblastic lymphoma than either CD10 or bcl-6. In addition, PD1 expression provides new evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T cells. PD1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T cells may undergo neoplastic transformation and result in Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
PD-L1/PDCD1-L1/CD274 [MD21R]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human -
PD-L1/PDCD1-L1/CD274 [MD21R]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse -
Pgp9.5/UCHL1 [31A3]
Description Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells, it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK PGP 9.5 has been demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine) -
Pgp9.5/UCHL1 [31A3]
Description Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells, it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK PGP 9.5 has been demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine)