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MSH2 [EPR21017-123]
Description MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€254,80 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MUC3 [M3.1]
Description Specificity & Comments It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadl Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC5AC [45M1]
Description Mucins are high molecular eight glycoproteins with 80% carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin M1 antigens are detected/found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in those of normal colon. Evidence from the literature suggestes that they are associated with the peptide core of mucins Resurgence of gastric mucin reactivity during colonic carcinogenesis is suggested to be due to either reexpression of the peptide core of gastric (or fetal colonic) mucins in the adult colon or due to changes in the glycosylation pattern of mucin which expose the hidden M1 antigens. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC5AC [45M1]
Description Mucins are high molecular eight glycoproteins with 80% carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin M1 antigens are detected/found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in those of normal colon. Evidence from the literature suggestes that they are associated with the peptide core of mucins Resurgence of gastric mucin reactivity during colonic carcinogenesis is suggested to be due to either reexpression of the peptide core of gastric (or fetal colonic) mucins in the adult colon or due to changes in the glycosylation pattern of mucin which expose the hidden M1 antigens. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
