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CD38 [AT1]
Description CD38, also called ADP-ribosyl cyclase, is a druggable ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. In particular, it synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B- and T-cell maturation. In normal lymph nodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells. An antibody to CD38 is helpful in the identification of plasma cells and tumors with plasmablastic differentiation. A prognostic value of CD38 in B-cell chronic lymphocytic leukemia (CLL) has been reported. Expression of CD38 is linked to unmutated IgVH genes and a worse prognosis. CD38 is involved in the generation of adenosine, which is implicated in tumor immune evasion. CD38 mRNA expression in metastatic castration-resistant prostate cancer (mCRPC) was most significantly associa Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
1 ml more info 
14 days 
€374,40 Add to cart -
CD38 [AT1]
Description CD38, also called ADP-ribosyl cyclase, is a druggable ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. In particular, it synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B- and T-cell maturation. In normal lymph nodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells. An antibody to CD38 is helpful in the identification of plasma cells and tumors with plasmablastic differentiation. A prognostic value of CD38 in B-cell chronic lymphocytic leukemia (CLL) has been reported. Expression of CD38 is linked to unmutated IgVH genes and a worse prognosis. CD38 is involved in the generation of adenosine, which is implicated in tumor immune evasion. CD38 mRNA expression in metastatic castration-resistant prostate cancer (mCRPC) was most significantly associa Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
