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CD38 [AT1]
Description CD38, also called ADP-ribosyl cyclase, is a druggable ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. In particular, it synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B- and T-cell maturation. In normal lymph nodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells. An antibody to CD38 is helpful in the identification of plasma cells and tumors with plasmablastic differentiation. A prognostic value of CD38 in B-cell chronic lymphocytic leukemia (CLL) has been reported. Expression of CD38 is linked to unmutated IgVH genes and a worse prognosis. CD38 is involved in the generation of adenosine, which is implicated in tumor immune evasion. CD38 mRNA expression in metastatic castration-resistant prostate cancer (mCRPC) was most significantly associa Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
CD4 [MT310]
Description CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with an antigen-presenting cell and also interacts directly with MHC class Ⅱ molecules on the surface of the antigen-presenting cells using its extracellular domain. In lymphatic tissues, the CD4+ T-cells are seen in large numbers in the parafollicular zone, while scattered cells are found in the germinal centres and mantle zone. CD4 is also demonstrated in hepatic sinusoidal cells, monocytes and monocytes-derived cells but not expressed on B-cells and immature thymocytes. Precursor T-lymphoblastic lymphomas are therefore variable in their expression of CD4. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas. (Shi Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
CD4 [MT310]
Description CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with an antigen-presenting cell and also interacts directly with MHC class Ⅱ molecules on the surface of the antigen-presenting cells using its extracellular domain. In lymphatic tissues, the CD4+ T-cells are seen in large numbers in the parafollicular zone, while scattered cells are found in the germinal centres and mantle zone. CD4 is also demonstrated in hepatic sinusoidal cells, monocytes and monocytes-derived cells but not expressed on B-cells and immature thymocytes. Precursor T-lymphoblastic lymphomas are therefore variable in their expression of CD4. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas. (Shi Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
CD42a [A9]
Description The CD42a antibody recognizes a 17 to 22-kilodalton (kDa) single-chain, platelet membrane glycoprotein, also known as gpIX that forms a noncovalent complex with gpIb and gpV. Glycoprotein Ib consists of an α–chain disulfide-linked to a β chain. Glycoproteins Ibα (140 to 145 kDa), Ibβ (24 to 25 kDa), and V (82 to 86 kDa) have been designated as CD42b, CD42c and CD42d respectively. CD42a has been reported to react with both gpIX and the gpIb-IX-V complex. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CD42b [42C01]
Description The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetin-induced aggregation and is involved in the binding of platelets to blood vessel walls. The CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. The absence of CD42b antigen on platelets may indicate Bernard-Soulier disease. CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€508,30 Add to cart -
CD42b [42C01]
Description The CD42b glycoprotein, also known as GPIb, is a co-factor of ristocetin-induced aggregation and is involved in the binding of platelets to blood vessel walls. The CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. The absence of CD42b antigen on platelets may indicate Bernard-Soulier disease. CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
CD44 (HCAM) [156-3C11]
Description CD44 is a cell-surface glycoprotein postulated to play a role in a variety of biological processes, including cell-to-cell and cell-to-matrix adhesion, lymphocyte homing and tumor cell metastasis. Several isoforms of CD44 have been identified in human cells, and the genesis of some of these isoforms has been attributed to alternative splicing. Understanding of mechanisms regulating CD44 alternative splicing may provide insights into diverse processes, including tumor-cell metastasis and lymphocyte homing. CD44 is widely expressed on many types of cells with mesodermal and hematopoietic origin, epithelial cells and a variety of tumors derived from these cells. Loss of CD44 expression has been linked to tumor invasion, metastasis and progression in carcinomas of breast, prostate, lung, ovary and malignant melanoma. Expressed on approximately 90% of lymphocytes, monocytes, granulocytes, and, in lower amounts on thymocytes, fibroblasts, and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Baboon, African green Monkey (Chlorocebus)
1 ml more info 14 days
€361,40 Add to cart -
CD44 (HCAM) [156-3C11]
Description CD44 is a cell-surface glycoprotein postulated to play a role in a variety of biological processes, including cell-to-cell and cell-to-matrix adhesion, lymphocyte homing and tumor cell metastasis. Several isoforms of CD44 have been identified in human cells, and the genesis of some of these isoforms has been attributed to alternative splicing. Understanding of mechanisms regulating CD44 alternative splicing may provide insights into diverse processes, including tumor-cell metastasis and lymphocyte homing. CD44 is widely expressed on many types of cells with mesodermal and hematopoietic origin, epithelial cells and a variety of tumors derived from these cells. Loss of CD44 expression has been linked to tumor invasion, metastasis and progression in carcinomas of breast, prostate, lung, ovary and malignant melanoma. Expressed on approximately 90% of lymphocytes, monocytes, granulocytes, and, in lower amounts on thymocytes, fibroblasts, and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Baboon, African green Monkey (Chlorocebus)
7 ml more info 14 days
€187,20 Add to cart -
CD45RA [111-1C5]
Description CD45 or Leukocyte Common Antigen (LCA/T200) belongs to a family of membrane sialoglycoproteins with MW of 180kDa-220kDa. Human CD45 contains three exons which encode peptidesegments designated A, B and C, respectively. The differential splicing of the exons generates various isoforms. CD45RA.is a single chain glycoprotein. It is expressed on appoximately 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. CD45RA are naive orvirgin T-cells while, T-cells expressing CD45RO are memory T-cells. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CD45RA [111-1C5]
Description CD45 or Leukocyte Common Antigen (LCA/T200) belongs to a family of membrane sialoglycoproteins with MW of 180kDa-220kDa. Human CD45 contains three exons which encode peptidesegments designated A, B and C, respectively. The differential splicing of the exons generates various isoforms. CD45RA.is a single chain glycoprotein. It is expressed on appoximately 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. CD45RA are naive orvirgin T-cells while, T-cells expressing CD45RO are memory T-cells. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
