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BRCA1-associated Protein 1 (BAP1) [C4]
Description The BRCA-1 gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The normal gene plays a role in repairing breaks in DNA. If a mutation occurs in this gene the repair function may become disabled thus leading to more DNA replication errors and neoplastic growth. Current findings suggest that BRCA-1 may play an as yet undefined protective role in cells, as it is strongly expressed in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional findings have det ermined that complete loss of BRCA-1 nuclear expression in breast cancer and the correlation with poor prognostic markers imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied for a potential rapid screening technique to identify BRCA-1 mutations (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human Mouse, Rat 
1 ml more info 
14 days 
€361,40 Add to cart -
Calcitonin Gene Related Peptide/CGRP [4901]
Description Calcitonin Gene Related Peptide or CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known. It is primarily produced in nervous tissue and its receptors are expressed throughout the body. CGRP is strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (PFA fixed), Immunohistochemistry on frozen sections (IHC-Fs), Immunoprecipitation (IP) Reactivity Human, Mouse, Rat, Dog Guinea Pig
1 ml more info 14 days
€374,40 Add to cart -
catalase [H9]
Description This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
catalase [H9]
Description This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog
1 ml more info 14 days
€374,40 Add to cart -
Cathepsin D [CTSD/3082]
Description Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and cancer progression. Cathepsin D is present in many types of cancer cells. In breast cancer, it is induced by estrogens and its expression is correlated with a higher risk of metastasis and poor disease-free survival. Extensive studies have been also performed to evaluate the clinical and therapeutic implication of Cathepsin D expression in nongynecological solid tumors. Although conflicting results have been observed in some reports, evidence emerging from these studies indicated that Cathepin D seems to facilitate early stages of tumor progression such as cell proliferation and local dissemination. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat,Pig (Porcine), Dog
7 ml more info 14 days
€187,20 Add to cart -
CD144/VE-Cadherin [16B1]
Description This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
CD147/EMMPRIN/Neurothelin [8D6]
Description This antibody recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD16 [DJ130C]
Description CD16 is a biomarker associated with monocytes and natural killer (NK) cells of the lymphoid lineage. Anti-CD16 immunohistochemistry is useful in differentially diagnosing hepatosplenic gamma delta T-cell lymphoma and gamma delta T-cell large granular lymphocyte leukemia from other peripheral T-cell lymphomas, such as mucosal and cutaneous gamma delta T-cell lymphoma. It is reported that 58% of hepatosplenic gamma delta T-cell lymphomas express CD16, and 86% of gamma delta T-cell large granular lymphocyte leukemias are immunoreactive with anti-CD16. Mucosal and cutaneous gamma delta T-cell lymphomas usually do not express CD16 antigen. A significant decrease can be seen in the number of granulocytes expressing CD16 in chronic myelomonocytic leukemia compared to chronic myelogenous leukemia and control bone marrow biopsy, probably related to dysgranulopoiesis. Bone marrow biopsy immunohistochemistry can be helpful in CMML by identifying both the monocyte expansion and the dysgranulopoies Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
CD16 [DJ130C]
Description CD16 is a biomarker associated with monocytes and natural killer (NK) cells of the lymphoid lineage. Anti-CD16 immunohistochemistry is useful in differentially diagnosing hepatosplenic gamma delta T-cell lymphoma and gamma delta T-cell large granular lymphocyte leukemia from other peripheral T-cell lymphomas, such as mucosal and cutaneous gamma delta T-cell lymphoma. It is reported that 58% of hepatosplenic gamma delta T-cell lymphomas express CD16, and 86% of gamma delta T-cell large granular lymphocyte leukemias are immunoreactive with anti-CD16. Mucosal and cutaneous gamma delta T-cell lymphomas usually do not express CD16 antigen. A significant decrease can be seen in the number of granulocytes expressing CD16 in chronic myelomonocytic leukemia compared to chronic myelogenous leukemia and control bone marrow biopsy, probably related to dysgranulopoiesis. Bone marrow biopsy immunohistochemistry can be helpful in CMML by identifying both the monocyte expansion and the dysgranulopoies Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
