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S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine 
1 ml more info 
14 days 
€361,40 Add to cart -
S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine
7 ml more info 14 days
€187,20 Add to cart -
S100P [MD197R]
Description S100P is a member of the S100 family of proteins. S100P is expressed in various normal tissues including placenta, bladder, spleen, gastric and intestinal mucosa. Overexpression of S100P has been detected in several cancers such as colon, prostate, pancreatic and lung carcinomas. It has been functionally implicated in carcinogenic processes. S100P is an early developmental marker of pancreatic carcinogenesis and can be used as a marker for pancreatic ductal adenocarcinoma. It may also serve as a predictor of distant metastasis and poor survival in non-small cell lung carcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€442,00 Add to cart -
S100P [MD197R]
Description S100P is a member of the S100 family of proteins. S100P is expressed in various normal tissues including placenta, bladder, spleen, gastric and intestinal mucosa. Overexpression of S100P has been detected in several cancers such as colon, prostate, pancreatic and lung carcinomas. It has been functionally implicated in carcinogenic processes. S100P is an early developmental marker of pancreatic carcinogenesis and can be used as a marker for pancreatic ductal adenocarcinoma. It may also serve as a predictor of distant metastasis and poor survival in non-small cell lung carcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
SDHB (Succinate Dehydrogenase B) [SDHB/2382]
Description Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. SDH catalyzes the oxidation of succinate to fumarate and transfers electrons to ubiquinone through the coordination of its four subunits (SDHA, SDHB, SDHC, and SDHD). The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. SDH subunit B (SDHB) is ubiquitously expressed in normal tissues. Germline mutations in SDHB, SDHC, or SDHD genes predispose development of phaeochromocytoma, paraganglioma and gastrointestinal stromal tumor (GIST). SDHB immunohistochemistry is helpful in the identification of phaeochromocytomas, paragangliomas or GIST with SDHB mutation. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
SDHB (Succinate Dehydrogenase B) [SDHB/2382]
Description Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. SDH catalyzes the oxidation of succinate to fumarate and transfers electrons to ubiquinone through the coordination of its four subunits (SDHA, SDHB, SDHC, and SDHD). The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. SDH subunit B (SDHB) is ubiquitously expressed in normal tissues. Germline mutations in SDHB, SDHC, or SDHD genes predispose development of phaeochromocytoma, paraganglioma and gastrointestinal stromal tumor (GIST). SDHB immunohistochemistry is helpful in the identification of phaeochromocytomas, paragangliomas or GIST with SDHB mutation. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Secretory Component/ECM1 [SC05]
Description This antibody is useful for studying the distribution and level of both free and bound Secretory Component. Secretory Component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory Component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential Secretory Component expression. This antibody reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking Secretory Component. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
Secretory Component/ECM1 [SC05]
Description This antibody is useful for studying the distribution and level of both free and bound Secretory Component. Secretory Component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory Component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential Secretory Component expression. This antibody reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking Secretory Component. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
SMAD4 (DPC4) [B-8]
Description Signaling from the ligand-activated membrane receptor serine/ threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DCP4. Upon ligand binding, the receptors of the TGF-β family phosphorylate SMAD proteins (SMAD1 and SMAD 2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expressionis is present in approximately 80% of cases of pancreatic adenocarcinoma, but rarely in endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2% adenocarcinomas, and malignant melanoma (4%). SMAD4 is an important marker for confirming a diagnosis of pancreat Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
SMAD4 (DPC4) [B-8]
Description Signaling from the ligand-activated membrane receptor serine/ threonine kinases to nuclear targets is mediated by a set of evolutionarily conserved proteins known as DCP4. Upon ligand binding, the receptors of the TGF-β family phosphorylate SMAD proteins (SMAD1 and SMAD 2). These proteins then move into the nucleus, where they activate transcription. To carry out this function, the receptor activated SMAD1 and 2 require association with the product of deleted in pancreatic carcinoma, locus 4 (DPC4), also known as SMAD4. SMAD4/DPC4 is also implicated as a tumor suppressor, since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expressionis is present in approximately 80% of cases of pancreatic adenocarcinoma, but rarely in endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2% adenocarcinomas, and malignant melanoma (4%). SMAD4 is an important marker for confirming a diagnosis of pancreat Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart
