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MMP1 [3B6]
Description Matrix metalloproteinases (MMPs), a family of peptidase enzymes, plays a critical role in degradation of extracellular matrix components in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated gelatinase B) has been shown to degrade bone collagens in concert with MMP1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP1 expression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Dog 
1 ml more info 
14 days 
€401,70 Add to cart -
Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
MSH2 [EPR21017-123]
Description MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€464,10 Add to cart -
MSH2 [EPR21017-123]
Description MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart
