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GFAP [GA-5]
Description Glial fibrillary acidic protein (GFAP) is the subunit of the glial specific “intermediate” filament that include desmin filaments in smooth muscle, vimentin filaments in cultured fibroblasts, keratin filaments in epithelium and neurofilaments in neural cells. GFAP is a major product of astrocytic differentiation. Compared with special stains currently used to identify an astroglial component in brain tumors, GFAP staining is more sensitive. Further, the immunohistochemical staining method is useful in demonstrating reactive astrocytes, whether secondary to a brain tumor or to any other neuro-pathological condition. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Mouse, Rat, Rabbit, Chicken, Bovine,Pig (Porcine) 
7 ml more info 
14 days 
€187,20 Add to cart -
Heat Shock Protein (HSP60) (Mitochondrial Marker) [LK1]
Description Recognizes a 60kDa protein, identified as the heat shock protein 60 (hsp60). Its epitope is localized between aa 383-447 of human hsp60. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (hsps), more appropriately called as stress response proteins (srps). hsp60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial hsp60, but also against its mammalian homolog. Clone LK1, unlike LK2, recognizes only the mammalian (not bacterial) hsp60 and is useful in distinguishing hsp60 from mammals and bacteria. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Sheep, Rabbit, Bovine, Dog (Canine),Pig (Porcine), Monkey, Chicken, Xenopus laevis, Drosophila
1 ml more info 14 days
€361,40 Add to cart -
Internexin Alpha/NF66 [2E3]
Description Alpha–internexin is an intermediate filament family member expressed during early neuron development and is related to the neurofilament proteins NF-H, NF-L and NF-M. Due to the specific spatial and temporal expression pattern of alpha-internexin, it is a useful marker of neuronal subtypes. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is downregulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. The very early developmental expression of alpha-internexin means its pr Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Cat, Rabbit, Bovine, Pig
1 ml more info 14 days
€374,40 Add to cart -
Internexin Alpha/NF66 [2E3]
Description Alpha–internexin is an intermediate filament family member expressed during early neuron development and is related to the neurofilament proteins NF-H, NF-L and NF-M. Due to the specific spatial and temporal expression pattern of alpha-internexin, it is a useful marker of neuronal subtypes. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is downregulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. The very early developmental expression of alpha-internexin means its pr Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Cat, Rabbit, Bovine, Pig
7 ml more info 14 days
€187,20 Add to cart -
Laminin Alpha 2/Merosin [5H2]
Description Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each laminin is a heterotrimer of α, β and γ chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble and bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan and cognate laminin receptors. The human Laminin α-2 gene is necessary for sustenance of mature muscle cells. The Laminin α-2 gene is associated with congenita. (Shipping Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey, Rabbit
1 ml more info 14 days
€361,40 Add to cart -
Myosin Skeletal Heavy Chain Fast/MYH1 [MY-32]
Description Myosin, a 480kD protein that interacts with actin in muscle and non muscle cells, is composed of 2 identical heavy chains (about 200kD each) and 4 light chains (about 20kD each). Conventional myosin molecules consist of two major regions: tail (rod) and globular heads; they aggregate into filaments through the tail region and interact with actin and with adenosine triphosphate (ATP) through the head region. Multiple forms of myosin heavy chains exist in skeletal, smooth and cardiac muscle and in non-muscle tissues. A spectrum of skeletal muscle fiber types is found in adult skeletal muscles. The two major skeletal muscle fiber types are type I (slow-twitch) and type II (fast-twitch). Skeletal muscle type II fibers can be further subdivided into types IIa (fast red) and IIb (fast white). (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Rabbit, Chicken, Guinea Pig, Bovine
1 ml more info 14 days
€429,00 Add to cart -
Myosin Skeletal Heavy Chain Slow/MYH7 [NOQ7.5.4D]
Description Myosin, a 480kD protein that interacts with actin in muscle and non muscle cells, is composed of 2 identical heavy chains (about 200kD each) and 4 light chains (about 20kD each). Conventional myosin molecules consist of two major regions: tail (rod) and globular heads; they aggregate into filaments through the tail region and interact with actin and with adenosine triphosphate (ATP) through the head region. Multiple forms of myosin heavy chains exist in skeletal, smooth and cardiac muscle and in non-muscle tissues. A spectrum of skeletal muscle fiber types is found in adult skeletal muscles. The two major skeletal muscle fiber types are type I (slow-twitch) and type II (fast-twitch). Type I muscle fibers are more efficient over long periods of time. They are mainly used for postural maintenance (such has holding the head upright), or endurance exercises (like marathon running). (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Radioimmunoassay (RIA), Western Blot (WB) Reactivity Human, Mouse, Rat, Rabbit, Chicken, Guinea Pig, Bovine, Sheep, Goat, Hamster, Cat, Dog (Canine),Pig (Porcine)
1 ml more info 14 days
€429,00 Add to cart -
S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine
1 ml more info 14 days
€361,40 Add to cart -
S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine
7 ml more info 14 days
€187,20 Add to cart -
Transgelin (SM22-alpha) [SPM606]
Description This antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine,Pig (Porcine), Rabbit, Mouse
1 ml more info 14 days
€361,40 Add to cart
