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cdc20 [AR12]
Description Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
cdc20 [AR12]
Description Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CDw75 [LN-1]
Description Cdw75 is proposed as the ligand for CD22 mediating B-cell-B-cell interaction. Clone LN1 recognizes a sialoantigen on cell membranes. On tissue sections, it causes a marked reaction with the B lymphocytes in germinal centers, but only a faint reaction with B lymphocytes of the mantle zone in lymphatic tissues. LN1 also reacts with various types of epithelial cells, including cells of the distal renal tubules, breast, bronchus, prostate and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CDw75 [LN-1]
Description Cdw75 is proposed as the ligand for CD22 mediating B-cell-B-cell interaction. Clone LN1 recognizes a sialoantigen on cell membranes. On tissue sections, it causes a marked reaction with the B lymphocytes in germinal centers, but only a faint reaction with B lymphocytes of the mantle zone in lymphatic tissues. LN1 also reacts with various types of epithelial cells, including cells of the distal renal tubules, breast, bronchus, prostate and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CDX2 [EP25]
Description The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey -
CEA/CD66 [CEA31]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
Chromogranin A [LK2H10]
Description Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. It is useful for identification of neuroendocrine tumors. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat -
c-Myb Phospho Ser11 [SZ04-81]
Description The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells. Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth. c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human