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MiTF (Microphthalmia Transcription Factor) [C5/D5]
Description MiTF is a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melanoma cells (but not other melanoma cell lines), as well as mast cells and heart. Clone D5 cocktail is especially designed for sensitive detection of MiTF protein. C5 reacts with both melanocytic and non-melanocytic isoforms of MiTF. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
MiTF (Microphthalmia Transcription Factor) [MITF/915]
Description MiTF is a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melanoma cells (but not other melanoma cell lines), as well as mast cells and heart. Clone D5 cocktail is especially designed for sensitive detection of MiTF protein. C5 reacts with both melanocytic and non-melanocytic isoforms of MiTF. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Dog
1 ml more info 14 days
€361,40 Add to cart -
MiTF (Microphthalmia Transcription Factor) [MITF/915]
Description MiTF is a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melanoma cells (but not other melanoma cell lines), as well as mast cells and heart. Clone D5 cocktail is especially designed for sensitive detection of MiTF protein. C5 reacts with both melanocytic and non-melanocytic isoforms of MiTF. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Dog
7 ml more info 14 days
€187,20 Add to cart -
MMP1 [3B6]
Description Matrix metalloproteinases (MMPs), a family of peptidase enzymes, plays a critical role in degradation of extracellular matrix components in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated gelatinase B) has been shown to degrade bone collagens in concert with MMP1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP1 expression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Dog
1 ml more info 14 days
€401,70 Add to cart -
Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC18/CD146/MCAM [MUC18/1130]
Description CD146 (melanoma-associated antigen A32), also known as MUC18, is a transmembrane glycoprotein expressed on endothelial cells and is located at the intercellular junction where it plays a role in cell adhesion, and in the cohesion of the endothelial monolayer. CD146 labels endothelial cells, smooth muscle cells, intermediate trophoblast, subpopulation of T cells, and peripheral neuronal cells. In tumor, CD146 is expressed on tumor cells derived from peripheral nerves system, melanoma and clear cell sarcoma. CD146 has been used as a marker for intermediate trophoblast. It has been reported that CD146 is useful in differentiation of mesothelioma (CD146 positive) and reactive mesothelium (CD146 negative). CD146 is associated with tumor progression and the development of metastasis in human malignant melanoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
