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EGFR [GFR/1667]
Description Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal of EGFR. Autophosphorylation of Tyr 992 creates a binding site for the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling. In breast cancer, EGFR is predorminately expressed in basal cell-like carcinoma, it has been recommendated for identification of basal-like breast carcinoma along with Cytokeratin 5/6. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
EGFR [GFR/1667]
Description Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal of EGFR. Autophosphorylation of Tyr 992 creates a binding site for the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling. In breast cancer, EGFR is predorminately expressed in basal cell-like carcinoma, it has been recommendated for identification of basal-like breast carcinoma along with Cytokeratin 5/6. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [139H2]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [139H2]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [SPM492]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [SPM492]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
EMI1 (Early Mitotic Inhibitor-1) [EMI1/1176]
Description It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Epithelial Antigen (Ep-Cam) [MOC-31]
Description Ep-CAM is a highly conserved type I transmembrane glycoprotein and is expressed on most normal and malignant epithlial cells. Ep-CAM is also known as epithelial cell adhesion molecule or MOC31, Ber-EP4. It is detected at the membrane/cytoplasm of the majority of epithelial tissues (all simple, pseudo-stratified and transitional epithelial), with the exception of the adult squamous epithelium and some epithelium-derived cells, such as hepatocytes, epidermal keratinocytes, gastric parietal cells, myoepithelial cells, and thymic cortical epithelium. In tumors, Ep-CAM is over expressed by the majority of human epithelial carcinomas, except hepatocellular carcinomas (HCC). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Epithelial Antigen (Ep-Cam) [MOC-31]
Description Ep-CAM is a highly conserved type I transmembrane glycoprotein and is expressed on most normal and malignant epithlial cells. Ep-CAM is also known as epithelial cell adhesion molecule or MOC31, Ber-EP4. It is detected at the membrane/cytoplasm of the majority of epithelial tissues (all simple, pseudo-stratified and transitional epithelial), with the exception of the adult squamous epithelium and some epithelium-derived cells, such as hepatocytes, epidermal keratinocytes, gastric parietal cells, myoepithelial cells, and thymic cortical epithelium. In tumors, Ep-CAM is over expressed by the majority of human epithelial carcinomas, except hepatocellular carcinomas (HCC). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
ER-beta [ERb455]
Description Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of r Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Mouse, Rat,Pig (Porcine), Horse, Sheep
1 ml more info 14 days
€361,40 Add to cart
