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CD95/FAS/TNFRSF9 [MD86]
Description The CD95 (Fas) protein is a cell surface receptor belonging to the tumor necrosis factor (TNF) family that transduces death signaling on engagement by multimeric Fas ligand (CD95L), of which there are eight in its membrane –bound form or in its soluble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95-mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis, and disruption of this death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fas death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human -
cdc20 [AR12]
Description Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
cdc20 [AR12]
Description Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CDw75 [LN-1]
Description Cdw75 is proposed as the ligand for CD22 mediating B-cell-B-cell interaction. Clone LN1 recognizes a sialoantigen on cell membranes. On tissue sections, it causes a marked reaction with the B lymphocytes in germinal centers, but only a faint reaction with B lymphocytes of the mantle zone in lymphatic tissues. LN1 also reacts with various types of epithelial cells, including cells of the distal renal tubules, breast, bronchus, prostate and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CDw75 [LN-1]
Description Cdw75 is proposed as the ligand for CD22 mediating B-cell-B-cell interaction. Clone LN1 recognizes a sialoantigen on cell membranes. On tissue sections, it causes a marked reaction with the B lymphocytes in germinal centers, but only a faint reaction with B lymphocytes of the mantle zone in lymphatic tissues. LN1 also reacts with various types of epithelial cells, including cells of the distal renal tubules, breast, bronchus, prostate and erythrocytes. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CEA/CD66 [CEA31]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human -
Chromogranin A [LK2H10]
Description Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. It is useful for identification of neuroendocrine tumors. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat -
c-Myc [MYC275+MYC909]
Description The c-MYC gene is located at chromosome 8q24. It is required for progression through the cell cycle and promotes cellular proliferation. The t(8;14)(q24;q32) translocation and the c-MYC/immunoglobulin heavy-chain (IGH) fusion gene are not only in Burkitt lymphoma, but are also seen in diffuse large B-cell lymphoma, blastic mantle cell lymphoma and transformed follicular lymphoma. In another study on predicting c-MYC translocation in 17 cases of Burkitt lymphomas (BLs) and 19 cases of diffuse large B-cell lymphomas (DLBCLs), Ruzinova et al. reported that the sensitivity and specificity of this c-Myc antibody on identifying tumor harboring a c-MYC rearrangement reached 96% and 90% respectively. This novel c-Myc antibody is a useful tool for identifying aggressive B-cell lymphomas likely to harbor a c-MYC rearrangement, and thus warrant genetic testing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human