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CD83 [HB15a]
Description CD83 is a 40-45kD glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express very low levels of CD83 after culture in agents such as Con A or PHA. In immunohistology, CD83 is shown to be expressed strongly by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres. CD83 is also expressed by Langerhan's cells in the skin. The CD83 antigen is a 186-amino-acid single-chain glycoprotein and this molecule is a member of the immunoglobulin superfamily that is composed of an extracellular V-type Ig-like single domain, a transmembrane region, and a short, 40-amino-acid cytoplasmic tail. CD83 antigen undergoes extensive post-translational glycosylation, since the determined Mr is twice the predicted size of the core protein. However, CD83+ cells have a unique cell surface immuno-phenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. CD83+ cells c Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
CD86/Dendritic Cells Maturation Marker [SPM600]
Description Recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
CDX2 [EP25]
Description The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
CEA/CD66 [CEA31]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
1 ml more info 14 days
€361,40 Add to cart -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CEA/CD66 [COL-1]
Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
c-Myb Phospho Ser11 [SZ04-81]
Description The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells. Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth. c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€546,00 Add to cart -
Cyclin D1 [DCS-6]
Description Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Cyclin D1 [DCS-6]
Description Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Cytochrome C [7H8.2C12]
Description Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC)/IF Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Horse, Dog (Canine), Pigeon, Frog, Drosophila
1 ml more info 14 days
€361,40 Add to cart
