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TLE1 [1F5]
Description Transducin-like enhancer of split 1 (TLE1) gene is a member of the TLE gene family and involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. By immunohistochemistry in formalin-fixed, paraffin-embedded tissues, TLE1 expression (nuclear staining) has been found in 35 of 35 molecularly confirmed synovial sarcoma cases, and was rare to absent in the 73 other soft tissue tumors examined (positive staining was found only in 1 of 43 malignant peripheral nerve sheath tumors and 1 pleomorphic sarcoma). Anti-TLE1 was more sensitive and specific for synovial sarcoma than other currently available immunohistochemical markers including BCL2, epithelial membrane antigen and cytokeratins, and had a positive predictive value of 92% and a negative predictive value of 100% in this clinical setting. TLE1 overexpression by immunohistochemistry is a highly sensitive and specific biomarker for the diagnosis of synovial sarcoma in the group of otherwise unclassifiable high Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC),Western Blot (WB) Reactivity Human 
1 ml more info 
14 days 
€546,00 Add to cart -
TLE1 [1F5]
Description Transducin-like enhancer of split 1 (TLE1) gene is a member of the TLE gene family and involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. By immunohistochemistry in formalin-fixed, paraffin-embedded tissues, TLE1 expression (nuclear staining) has been found in 35 of 35 molecularly confirmed synovial sarcoma cases, and was rare to absent in the 73 other soft tissue tumors examined (positive staining was found only in 1 of 43 malignant peripheral nerve sheath tumors and 1 pleomorphic sarcoma). Anti-TLE1 was more sensitive and specific for synovial sarcoma than other currently available immunohistochemical markers including BCL2, epithelial membrane antigen and cytokeratins, and had a positive predictive value of 92% and a negative predictive value of 100% in this clinical setting. TLE1 overexpression by immunohistochemistry is a highly sensitive and specific biomarker for the diagnosis of synovial sarcoma in the group of otherwise unclassifiable high Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC),Western Blot (WB) Reactivity Human
7 ml more info 14 days
€267,80 Add to cart -
Topoisomerase II alpha [TOP2A/1362]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Topoisomerase II alpha [TOP2A/1362]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Villin [VIL1/1314]
Description Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs. This antibody also labels Merkel cells of the skin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Villin [VIL1/1314]
Description Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs. This antibody also labels Merkel cells of the skin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
1 ml more info 14 days
€507,00 Add to cart -
TRPS1 [EPR16171]
Description Trichorhinophalangeal syndrome I (TRPS1), a transcriptional repressor, binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1. TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor. It is expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
Monoclonal antibody to human IFN-gamma (clone MD-1)
Description The monoclonal antibody to human IFN-γ (clone MD-1) was first described in 1985. It has shown to neutralize the antiviral activity of both natural and recombinant human IFN-γ and in a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-γ. The MD-1 antibody has been descripted as useful in a sandwich ELISA and in ELISPOT assays. Further, the antibody has proven to cross react with chimpanzee and rhesus macaque IFN-γ and can be used for immunohistochemical staining of frozen tissues. The MD-1 antibody has been reported for use in intracellular flow cytometric analysis and in Luminex systems. Other available formats: biotin labeled (cat. no. CT218) and FITC labeled (cat. no. CT220). (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Chimpanzee,Rhesus Macaque
0 0.5 mg more info 8 days
€325,00 Add to cart -
Monoclonal antibody to monkey IFN-gamma (clone MD-1)
Description The neutralizing monoclonal antibody to monkey IFN-γ (clone MD-1) was first described in 1985. The MD-1 antibody can be used in a sandwich ELISA and in ELISPOT assays. Further, the antibody has been descripted in immunohistochemical staining of frozen tissues of marmosets and in intracellular flow cytometric analysis. The MD-1 antibody has been reported to cross react with rhesus macaque, pig-tailed macaque, cynomogus monkey, baboon and African green monkey IFN-γ and can be used in Luminex systems. (Shipping cost: €30.00; Handling cost €30.00 - €50.00) Host Mouse Application ELISA,Enzyme-linked immunosorbent spot (ELISPOT),Flow cytometry (FC),Immunohistochemistry on frozen sections (IHC-Fs),Neutralization (Neut),Western Blot (WB) Reactivity Rhesus Macaque,Cynomolgus Monkey,Pig-tailed Macaque,Japanese Macaque,Crested Black Macaque,Barbary Macaque,Lion-tailed Macaque,Baboon,Mandrill,African Green Monkey (Chlorocebus),Black Mangabey
0 mg more info 8 days
€325,00 Add to cart
