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  • Article number: MC0323RTU7
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    CEA/CD66 [COL-1]

    Description Carcinoembryonic Antigen (CEA), also known as CD66e, is a cell surface glycoprotein that exhibits several functions, includingregulation of intercellular adhesion, differentiation and anoikis, cell polarization and tissue architecture. CEA is present in fetal colon and many types of epithelial tumors, including adenocarcinomas of the GI tract, lung and breast. Antibody to CEA is useful in differentiating lung adenocarcinoma (positive) from mesothelioma (negative). CEA has been helpful in monitoring tumor progression. (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
    Reactivity Human
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €187,20 
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  • Article number: MC0726
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    Chromogranin A [LK2H10]

    Description Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. It is useful for identification of neuroendocrine tumors. (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
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  • Article number: RM0410
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    c-Myb Phospho Ser11 [SZ04-81]

    Description The c-Myb proto-oncogene is a 75 kDa protein involved in growth regulation and differentiation in many different cell types but it is predominantly expressed in immature hemopoietic cells where it plays an important role in cell proliferation. c-Myb activity is directly regulated by cyclin D1 and CDKs and it is believed that c-Myb activity is regulated during the cell cycle in hematopoietic cells. Disrupting c-myb function might, therefore, prove an effective therapeutic strategy for controlling leukemic cell growth. c-Myb binds to promoter sequences of genes such as c-Myc or Bcl-2 that are expressed in cutaneous T-cell lymphoma. (Shipping Cost: €200.00)
    Host Rabbit
    Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
    Reactivity Human
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €546,00 
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  • Article number: MC0134
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    c-Myc [MYC275+MYC909]

    Description The c-MYC gene is located at chromosome 8q24. It is required for progression through the cell cycle and promotes cellular proliferation. The t(8;14)(q24;q32) translocation and the c-MYC/immunoglobulin heavy-chain (IGH) fusion gene are not only in Burkitt lymphoma, but are also seen in diffuse large B-cell lymphoma, blastic mantle cell lymphoma and transformed follicular lymphoma. In another study on predicting c-MYC translocation in 17 cases of Burkitt lymphomas (BLs) and 19 cases of diffuse large B-cell lymphomas (DLBCLs), Ruzinova et al. reported that the sensitivity and specificity of this c-Myc antibody on identifying tumor harboring a c-MYC rearrangement reached 96% and 90% respectively. This novel c-Myc antibody is a useful tool for identifying aggressive B-cell lymphomas likely to harbor a c-MYC rearrangement, and thus warrant genetic testing (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
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  • Article number: MC0134RTU7
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    c-Myc [MYC275+MYC909]

    Description The c-MYC gene is located at chromosome 8q24. It is required for progression through the cell cycle and promotes cellular proliferation. The t(8;14)(q24;q32) translocation and the c-MYC/immunoglobulin heavy-chain (IGH) fusion gene are not only in Burkitt lymphoma, but are also seen in diffuse large B-cell lymphoma, blastic mantle cell lymphoma and transformed follicular lymphoma. In another study on predicting c-MYC translocation in 17 cases of Burkitt lymphomas (BLs) and 19 cases of diffuse large B-cell lymphomas (DLBCLs), Ruzinova et al. reported that the sensitivity and specificity of this c-Myc antibody on identifying tumor harboring a c-MYC rearrangement reached 96% and 90% respectively. This novel c-Myc antibody is a useful tool for identifying aggressive B-cell lymphomas likely to harbor a c-MYC rearrangement, and thus warrant genetic testing (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €187,20 
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  • Article number: RM0407
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    CXCR4/CD184 [MD45R]

    Description The C-X-C or a chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemo-attractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB and CXCR4 (also known as LESTR or fusin). CXCR4 is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. CXCR4 has been identified as the major co-receptor for T-tropic HIV-1 and SDF-1 has been shown to inhibit HIV-1 infection. (Shipping Cost: €200.00)
    Host Rabbit
    Application Flow cytometry (FC), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €455,00 
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  • Article number: RM0407RTU7
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    CXCR4/CD184 [MD45R]

    Description The C-X-C or a chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemo-attractant for T cells and monocytes but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins which include IL-8RA, IL-8RB and CXCR4 (also known as LESTR or fusin). CXCR4 is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. CXCR4 has been identified as the major co-receptor for T-tropic HIV-1 and SDF-1 has been shown to inhibit HIV-1 infection. (Shipping Cost: €200.00)
    Host Mouse
    Application Flow cytometry (FC), Immunohistochemistry (IHC)
    Reactivity Human
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €234,00 
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  • Article number: MC0730
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    Cyclin B1 [CCNB1/1098]

    Description Cyclins are a family of proteins that activate specific cyclin-dependent kinases required for progression through the cell cycle. The entry of all eukaryotic cells into mitosis is regulated by activation of cdc2/cdk1 at the G2/M transition. This activation is a multi-step process that begins with the binding of the regulatory subunit, cyclin B1, to cdc2/cdk1 to form the mitosis-promoting factor (MPF). MPF remains in the inactive state until phosphorylation of cdc2/cdk1 at Thr161 by cdk activating kinase (CAK) (1,2) and dephosphorylation of cdc2/cdk1 at Thr14/Tyr15 by cdc25C. Five cyclin B1 phosphorylation sites (Ser116, 126, 128, 133, and 147) are located in the cytoplasmic retention signal (CRS) domain and are thought to regulate the translocation of cyclin B1 to the nucleus at the G2/M checkpoint, promoting nuclear accumulation and initiation of mitosis. While MPF itself can phosphorylate Ser126 and Ser128, polo-like kinase 1 (PLK1) phosphorylates cyclin B1 preferentially at Ser133 a
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human, Mouse
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
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  • Article number: MC0730RTU7
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    Cyclin B1 [CCNB1/1098]

    Description Cyclins are a family of proteins that activate specific cyclin-dependent kinases required for progression through the cell cycle. The entry of all eukaryotic cells into mitosis is regulated by activation of cdc2/cdk1 at the G2/M transition. This activation is a multi-step process that begins with the binding of the regulatory subunit, cyclin B1, to cdc2/cdk1 to form the mitosis-promoting factor (MPF). MPF remains in the inactive state until phosphorylation of cdc2/cdk1 at Thr161 by cdk activating kinase (CAK) (1,2) and dephosphorylation of cdc2/cdk1 at Thr14/Tyr15 by cdc25C. Five cyclin B1 phosphorylation sites (Ser116, 126, 128, 133, and 147) are located in the cytoplasmic retention signal (CRS) domain and are thought to regulate the translocation of cyclin B1 to the nucleus at the G2/M checkpoint, promoting nuclear accumulation and initiation of mitosis. While MPF itself can phosphorylate Ser126 and Ser128, polo-like kinase 1 (PLK1) phosphorylates cyclin B1 preferentially at Ser133 a
    Host Mouse
    Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Reactivity Human, Mouse
    Unit 7 ml
    more info
    Normal leadtime 14 days
    Calculated total €187,20 
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  • Article number: MC0732
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    Cyclin D1 [DCS-6]

    Description Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones. (Shipping Cost: €200.00)
    Host Mouse
    Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
    Reactivity Human, Mouse, Rat
    Unit 1 ml
    more info
    Normal leadtime 14 days
    Calculated total €361,40 
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