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PSAP (Prostatic or Prostate Specific Acid Phosphatase) [PASE/4LJ]
Description Prostate Specific Acid Phosphatase (PSAP) is a 100 kD glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is measured clinically because its level often rises in the serum in cases of prostatic carcinoma. By immunohistochemical analysis PSAP has been found concentrated within the large secretory vacuoles of the supranuclear portion of the prostatic columnar epithelial cell. In hyperplastic prostates and in benign prostatic tissue adjacent to the prostatic carcinoma, PSAP activity is limited to the acinar or ductal columnar epithelial cells and adjacent luminal content. PSAP reactivity in an extraprostatic tumor is an accurate and sensitive indicator of metastatic prostatic carcinoma. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
Renal Cell Carcinoma (RCC)/Proximal Nephrogenic Antigen [66.4.C2]
Description Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately 90% of primary renal cell carcinomas and approximately 85% of metastatic renal cell carcinomas. Therefore, anti-RCC is a reliable tool for differentiating primary or metastatic renal cell carcinoma from non-renal tumors. It may be utilized as a marker for the differential diagnosis of eosinophilic renal tumors-granular variant of renal cell carcinoma, chromophobe renal cell carcinoma, and oncocytoma. Other tumors that may react with this antibody are parathyroid adenoma and an occasional breast carcinoma. Nephroblastoma, oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Horse -
Renal Cell Carcinoma (RCC)/Proximal Nephrogenic Antigen [66.4.C2]
Description Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately 90% of primary renal cell carcinomas and approximately 85% of metastatic renal cell carcinomas. Therefore, anti-RCC is a reliable tool for differentiating primary or metastatic renal cell carcinoma from non-renal tumors. It may be utilized as a marker for the differential diagnosis of eosinophilic renal tumors-granular variant of renal cell carcinoma, chromophobe renal cell carcinoma, and oncocytoma. Other tumors that may react with this antibody are parathyroid adenoma and an occasional breast carcinoma. Nephroblastoma, oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Horse -
S100 [4C4.9]
Description S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine -
S100 [4C4.9]
Description S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine -
S100A9/MRP14 [47-8D3]
Description S100A9 or MRP14, is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. It forms a heterodimer, Calprotectin, with S100A8 in a calcium-dependent manner. S100A9 may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. S100A9 is expressed in granulocytes, monocytes in peripheral blood and in infiltrating macrophages in inflammatory sites but not in normal tissue macrophages. Elevated plasma levels of S100A9 have been observed in inflammatory disorders such as chronic bronchitis, cystic fibrosis and rheumatoid arthritis. S100A9 is also detected in tumor cells in carcinomas of the liver, lung, breast and thyroid. The expression of S100A9 is correlated with tumor differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
S100A9/MRP14 [47-8D3]
Description S100A9 or MRP14, is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. It forms a heterodimer, Calprotectin, with S100A8 in a calcium-dependent manner. S100A9 may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. S100A9 is expressed in granulocytes, monocytes in peripheral blood and in infiltrating macrophages in inflammatory sites but not in normal tissue macrophages. Elevated plasma levels of S100A9 have been observed in inflammatory disorders such as chronic bronchitis, cystic fibrosis and rheumatoid arthritis. S100A9 is also detected in tumor cells in carcinomas of the liver, lung, breast and thyroid. The expression of S100A9 is correlated with tumor differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine -
S100B [SH-B1]
Description S100 Beta is a homodimeric member of the S100 superfamily. S100 is a family of Ca2+-binding proteins, comprised of 19 members that are differentially expressed in a large number of cell types. The protein has been implicated in cellular processes such as cell differentiation and growth. S100 Beta is abundant in glial cells of the central and peripheral nervous system, in melanocytes, chondrocytes, and adipocytes. It also labels Langerhans cells, histiocytes, epithelial cells, myoepithelial cells and integrating reticular cells of lymphoid tissue, and tumors originated from these cells. S100 Beta is a useful marker for diagnosis of melanoma and tumors of nervous system. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Rabbit, Cat, Bovine -
S100P [MD197R]
Description S100P is a member of the S100 family of proteins. S100P is expressed in various normal tissues including placenta, bladder, spleen, gastric and intestinal mucosa. Overexpression of S100P has been detected in several cancers such as colon, prostate, pancreatic and lung carcinomas. It has been functionally implicated in carcinogenic processes. S100P is an early developmental marker of pancreatic carcinogenesis and can be used as a marker for pancreatic ductal adenocarcinoma. It may also serve as a predictor of distant metastasis and poor survival in non-small cell lung carcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry on paraffin sections (IHC-P), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human